Mesenchymal stem cells for osteoarthritis: Recent advances in related cell therapy
Abstract Osteoarthritis (OA) is a degenerative joint disease that affects the entire joint and has been a huge burden on the health care system worldwide. Although traditional therapy and targeted cartilage cell therapy have made significant progress in the treatment of OA and cartilage regeneration...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Bioengineering & Translational Medicine |
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| Online Access: | https://doi.org/10.1002/btm2.10701 |
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| author | Jianjing Lin Jingtao Huang Zilu Jiao Mengyuan Nian Canfeng Li Yali Dai Shicheng Jia Xintao Zhang |
| author_facet | Jianjing Lin Jingtao Huang Zilu Jiao Mengyuan Nian Canfeng Li Yali Dai Shicheng Jia Xintao Zhang |
| author_sort | Jianjing Lin |
| collection | DOAJ |
| description | Abstract Osteoarthritis (OA) is a degenerative joint disease that affects the entire joint and has been a huge burden on the health care system worldwide. Although traditional therapy and targeted cartilage cell therapy have made significant progress in the treatment of OA and cartilage regeneration, there are still many problems. Mesenchymal stem cells from various tissues are the most studied cell type and have been used in preclinical and clinical studies of OA, because they are more widely available, have a greater capacity for in vitro expansion, and have anti‐inflammatory and immunomodulatory properties compared to autologous chondrocytes. This article will systematically review the latest developments in these areas. It may provide new insights for improving OA and cartilage regeneration. |
| format | Article |
| id | doaj-art-b3c1c3902ed04ca89a1bceada359654f |
| institution | Kabale University |
| issn | 2380-6761 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioengineering & Translational Medicine |
| spelling | doaj-art-b3c1c3902ed04ca89a1bceada359654f2025-01-09T06:19:46ZengWileyBioengineering & Translational Medicine2380-67612025-01-01101n/an/a10.1002/btm2.10701Mesenchymal stem cells for osteoarthritis: Recent advances in related cell therapyJianjing Lin0Jingtao Huang1Zilu Jiao2Mengyuan Nian3Canfeng Li4Yali Dai5Shicheng Jia6Xintao Zhang7Department of Sports Medicine and Rehabilitation Peking University Shenzhen Hospital Shenzhen ChinaDepartment of Sports Medicine and Rehabilitation Peking University Shenzhen Hospital Shenzhen ChinaDepartment of Sports Medicine and Rehabilitation Peking University Shenzhen Hospital Shenzhen ChinaCardre Health Care Department Peking University Shenzhen Hospital Shenzhen ChinaDepartment of Sports Medicine and Rehabilitation Peking University Shenzhen Hospital Shenzhen ChinaCardre Health Care Department Peking University Shenzhen Hospital Shenzhen ChinaDepartment of Sports Medicine and Rehabilitation Peking University Shenzhen Hospital Shenzhen ChinaDepartment of Sports Medicine and Rehabilitation Peking University Shenzhen Hospital Shenzhen ChinaAbstract Osteoarthritis (OA) is a degenerative joint disease that affects the entire joint and has been a huge burden on the health care system worldwide. Although traditional therapy and targeted cartilage cell therapy have made significant progress in the treatment of OA and cartilage regeneration, there are still many problems. Mesenchymal stem cells from various tissues are the most studied cell type and have been used in preclinical and clinical studies of OA, because they are more widely available, have a greater capacity for in vitro expansion, and have anti‐inflammatory and immunomodulatory properties compared to autologous chondrocytes. This article will systematically review the latest developments in these areas. It may provide new insights for improving OA and cartilage regeneration.https://doi.org/10.1002/btm2.10701cartilageextracellular vesiclesmesenchymal stem cellsosteoarthritisstem cell |
| spellingShingle | Jianjing Lin Jingtao Huang Zilu Jiao Mengyuan Nian Canfeng Li Yali Dai Shicheng Jia Xintao Zhang Mesenchymal stem cells for osteoarthritis: Recent advances in related cell therapy Bioengineering & Translational Medicine cartilage extracellular vesicles mesenchymal stem cells osteoarthritis stem cell |
| title | Mesenchymal stem cells for osteoarthritis: Recent advances in related cell therapy |
| title_full | Mesenchymal stem cells for osteoarthritis: Recent advances in related cell therapy |
| title_fullStr | Mesenchymal stem cells for osteoarthritis: Recent advances in related cell therapy |
| title_full_unstemmed | Mesenchymal stem cells for osteoarthritis: Recent advances in related cell therapy |
| title_short | Mesenchymal stem cells for osteoarthritis: Recent advances in related cell therapy |
| title_sort | mesenchymal stem cells for osteoarthritis recent advances in related cell therapy |
| topic | cartilage extracellular vesicles mesenchymal stem cells osteoarthritis stem cell |
| url | https://doi.org/10.1002/btm2.10701 |
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