Phosphodiesterase Type 4D Gene Polymorphism: Association with the Response to Short-Acting Bronchodilators in Paediatric Asthma Patients
Short-acting b2-adrenergic receptor agonists are commonly used bronchodilators for symptom relief in asthmatics. The aim of this study was to test whether genetic variants in PDE4D gene, a key regulator of b2-adrenoceptor-induced cAMP turnover in airway smooth muscle cells, affect the response to sh...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2011/301695 |
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| author | Malgorzata Labuda Sophie Laberge Julie Brière Denis Bérubé Patrick Beaulieu Tomi Pastinen Maja Krajinovic |
| author_facet | Malgorzata Labuda Sophie Laberge Julie Brière Denis Bérubé Patrick Beaulieu Tomi Pastinen Maja Krajinovic |
| author_sort | Malgorzata Labuda |
| collection | DOAJ |
| description | Short-acting b2-adrenergic receptor agonists are commonly used bronchodilators for symptom relief in asthmatics. The aim of this study was to test whether genetic variants in PDE4D gene, a key regulator of b2-adrenoceptor-induced cAMP turnover in airway smooth muscle cells, affect the response to short-acting b2-agonists. Bronchodilator responsiveness was assessed in 133 asthmatic children by % change in baseline forced expiratory volume in one second (FEV1) after administration of albuterol. The analyses were performed in patients with airway obstruction (FEV1/FVC ratio below 90%, n=93). FEV1 % change adjusted for baseline FEV1 values was significantly different between genotypes of rs1544791 G/A polymorphism (P=0.006) and −1345 C/T (rs1504982) promoter variation (P=0.03). The association remained significant with inclusion of age, sex, atopy, and controller medication into multivariate model (P=0.004
and P=0.02, resp.). Our work identifies new genetic variants implicated in modulation of asthma treatment, one of them (rs1544791) previously associated with asthma phenotype. |
| format | Article |
| id | doaj-art-b3c152a6c2d04fa4a45577a95a46484a |
| institution | DOAJ |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-b3c152a6c2d04fa4a45577a95a46484a2025-08-20T03:20:52ZengWileyMediators of Inflammation0962-93511466-18612011-01-01201110.1155/2011/301695301695Phosphodiesterase Type 4D Gene Polymorphism: Association with the Response to Short-Acting Bronchodilators in Paediatric Asthma PatientsMalgorzata Labuda0Sophie Laberge1Julie Brière2Denis Bérubé3Patrick Beaulieu4Tomi Pastinen5Maja Krajinovic6Research Center, CHU Sainte-Justine, Montreal, QC, H3T 1C5, CanadaDepartment of Paediatrics, University of Montreal, Montreal, Qc, H3T 1C5, CanadaResearch Center, CHU Sainte-Justine, Montreal, QC, H3T 1C5, CanadaDepartment of Paediatrics, University of Montreal, Montreal, Qc, H3T 1C5, CanadaResearch Center, CHU Sainte-Justine, Montreal, QC, H3T 1C5, CanadaDepartment of Human Genetics, McGill University and Génome Québec Innovation Centre, Montreal, Qc, H3A 1A4, CanadaResearch Center, CHU Sainte-Justine, Montreal, QC, H3T 1C5, CanadaShort-acting b2-adrenergic receptor agonists are commonly used bronchodilators for symptom relief in asthmatics. The aim of this study was to test whether genetic variants in PDE4D gene, a key regulator of b2-adrenoceptor-induced cAMP turnover in airway smooth muscle cells, affect the response to short-acting b2-agonists. Bronchodilator responsiveness was assessed in 133 asthmatic children by % change in baseline forced expiratory volume in one second (FEV1) after administration of albuterol. The analyses were performed in patients with airway obstruction (FEV1/FVC ratio below 90%, n=93). FEV1 % change adjusted for baseline FEV1 values was significantly different between genotypes of rs1544791 G/A polymorphism (P=0.006) and −1345 C/T (rs1504982) promoter variation (P=0.03). The association remained significant with inclusion of age, sex, atopy, and controller medication into multivariate model (P=0.004 and P=0.02, resp.). Our work identifies new genetic variants implicated in modulation of asthma treatment, one of them (rs1544791) previously associated with asthma phenotype.http://dx.doi.org/10.1155/2011/301695 |
| spellingShingle | Malgorzata Labuda Sophie Laberge Julie Brière Denis Bérubé Patrick Beaulieu Tomi Pastinen Maja Krajinovic Phosphodiesterase Type 4D Gene Polymorphism: Association with the Response to Short-Acting Bronchodilators in Paediatric Asthma Patients Mediators of Inflammation |
| title | Phosphodiesterase Type 4D Gene Polymorphism: Association with the Response to Short-Acting Bronchodilators in Paediatric Asthma Patients |
| title_full | Phosphodiesterase Type 4D Gene Polymorphism: Association with the Response to Short-Acting Bronchodilators in Paediatric Asthma Patients |
| title_fullStr | Phosphodiesterase Type 4D Gene Polymorphism: Association with the Response to Short-Acting Bronchodilators in Paediatric Asthma Patients |
| title_full_unstemmed | Phosphodiesterase Type 4D Gene Polymorphism: Association with the Response to Short-Acting Bronchodilators in Paediatric Asthma Patients |
| title_short | Phosphodiesterase Type 4D Gene Polymorphism: Association with the Response to Short-Acting Bronchodilators in Paediatric Asthma Patients |
| title_sort | phosphodiesterase type 4d gene polymorphism association with the response to short acting bronchodilators in paediatric asthma patients |
| url | http://dx.doi.org/10.1155/2011/301695 |
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