Adolescent binge alcohol exposure accelerates Alzheimer’s disease-associated basal forebrain neuropathology through proinflammatory HMGB1 signaling

Adolescent binge alcohol exposure accelerates Alzheimer’s disease-associated basal forebrain neuropathology through proinflammatory HMGB1 signaling

Human studies suggest that heavy alcohol use may be an etiological factor contributing to the development of Alzheimer’s disease (AD) neuropathology. Both alcohol use disorder (AUD) and AD share common underlying neuropathology, including proinflammatory high-mobility group box 1 (HMGB1)-mediated ne...

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Bibliographic Details
Main Authors: Rachael P. Fisher, Lindsay Matheny, Sarrah Ankeny, Liya Qin, Leon G. Coleman, Ryan P. Vetreno
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Aging Neuroscience
Subjects:
ethanol
neuroinflammation
microglia
cholinergic neurons
HMGB1
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1531628/full
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