Cinacalcet for Infants and Young Children on Maintenance Dialysis: Determining the Right Time, the Right Dose and the Right Patients
Chronic Kidney Disease - Mineral Bone Disorder (CKD-MBD) is a recognized complication of kidney failure, which can lead to short stature, bone deformity, slipped capital femoral epiphysis, and bone fracture in children. Despite the use of conventional therapies, a subgroup of patients receiving dial...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Kidney International Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468024924020540 |
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| author | Kyle Ying-kit Lin Fiona Fung-yee Lai Eugene Yu-hin Chan Bradley A. Warady |
| author_facet | Kyle Ying-kit Lin Fiona Fung-yee Lai Eugene Yu-hin Chan Bradley A. Warady |
| author_sort | Kyle Ying-kit Lin |
| collection | DOAJ |
| description | Chronic Kidney Disease - Mineral Bone Disorder (CKD-MBD) is a recognized complication of kidney failure, which can lead to short stature, bone deformity, slipped capital femoral epiphysis, and bone fracture in children. Despite the use of conventional therapies, a subgroup of patients receiving dialysis continues to experience secondary or even tertiary hyperparathyroidism. Cinacalcet, a calcimimetic agent, has been shown to be a promising therapeutic option to control hyperparathyroidism with reasonable safety profiles in adults and older children. Nevertheless, there is a paucity of data and guidance pertaining to its use among the younger children on dialysis, who are often the most challenging patients to manage with severe CKD-MBD. In this review, we summarize the available evidence on cinacalcet use among pediatric patients, especially infants and young children aged < 3 years. We also discuss the unique considerations in management and attempt to provide a pragmatic approach regarding the use of cinacalcet in this specific patient population. |
| format | Article |
| id | doaj-art-b3bdd880605541ff8902829ed8e937d3 |
| institution | OA Journals |
| issn | 2468-0249 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Kidney International Reports |
| spelling | doaj-art-b3bdd880605541ff8902829ed8e937d32025-08-20T02:06:00ZengElsevierKidney International Reports2468-02492025-03-0110369670610.1016/j.ekir.2024.11.032Cinacalcet for Infants and Young Children on Maintenance Dialysis: Determining the Right Time, the Right Dose and the Right PatientsKyle Ying-kit Lin0Fiona Fung-yee Lai1Eugene Yu-hin Chan2Bradley A. Warady3Paediatric Nephrology Center, Hong Kong Children’s Hospital, Hong Kong SAR, ChinaPaediatric Nephrology Center, Hong Kong Children’s Hospital, Hong Kong SAR, China; Department of Pharmacy, Hong Kong Children’s Hospital, Hong Kong SAR, ChinaPaediatric Nephrology Center, Hong Kong Children’s Hospital, Hong Kong SAR, China; Department of Pediatrics, The Chinese University of Hong Kong, Hong Kong SAR, China; Correspondence: Eugene Yu-hin Chan, Pediatric Nephrology Center, Hong Kong Children’s Hospital, Kowloon Bay, Hong Kong SAR, China.Division of Pediatric Nephrology, Children’s Mercy Kansas City, Kansas City, Missouri, USA; Bradley A. Warady, Division of Nephrology, Children’s Mercy Kansas City, 2401 Gillham Road, Kansas City, Missouri 64108, USA.Chronic Kidney Disease - Mineral Bone Disorder (CKD-MBD) is a recognized complication of kidney failure, which can lead to short stature, bone deformity, slipped capital femoral epiphysis, and bone fracture in children. Despite the use of conventional therapies, a subgroup of patients receiving dialysis continues to experience secondary or even tertiary hyperparathyroidism. Cinacalcet, a calcimimetic agent, has been shown to be a promising therapeutic option to control hyperparathyroidism with reasonable safety profiles in adults and older children. Nevertheless, there is a paucity of data and guidance pertaining to its use among the younger children on dialysis, who are often the most challenging patients to manage with severe CKD-MBD. In this review, we summarize the available evidence on cinacalcet use among pediatric patients, especially infants and young children aged < 3 years. We also discuss the unique considerations in management and attempt to provide a pragmatic approach regarding the use of cinacalcet in this specific patient population.http://www.sciencedirect.com/science/article/pii/S2468024924020540childrencinacalcetCKD-MBDdialysisESKDpediatric nephrology |
| spellingShingle | Kyle Ying-kit Lin Fiona Fung-yee Lai Eugene Yu-hin Chan Bradley A. Warady Cinacalcet for Infants and Young Children on Maintenance Dialysis: Determining the Right Time, the Right Dose and the Right Patients Kidney International Reports children cinacalcet CKD-MBD dialysis ESKD pediatric nephrology |
| title | Cinacalcet for Infants and Young Children on Maintenance Dialysis: Determining the Right Time, the Right Dose and the Right Patients |
| title_full | Cinacalcet for Infants and Young Children on Maintenance Dialysis: Determining the Right Time, the Right Dose and the Right Patients |
| title_fullStr | Cinacalcet for Infants and Young Children on Maintenance Dialysis: Determining the Right Time, the Right Dose and the Right Patients |
| title_full_unstemmed | Cinacalcet for Infants and Young Children on Maintenance Dialysis: Determining the Right Time, the Right Dose and the Right Patients |
| title_short | Cinacalcet for Infants and Young Children on Maintenance Dialysis: Determining the Right Time, the Right Dose and the Right Patients |
| title_sort | cinacalcet for infants and young children on maintenance dialysis determining the right time the right dose and the right patients |
| topic | children cinacalcet CKD-MBD dialysis ESKD pediatric nephrology |
| url | http://www.sciencedirect.com/science/article/pii/S2468024924020540 |
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