Protective effects of turmeric extract, curcumin, demethoxycurcumin, bis-demethoxycurcumin, and ar-turmerone from Curcuma longa L. rhizomes on acetaminophen-induced hepatotoxicity in HepG2 cells

Protective effects of turmeric extract, curcumin, demethoxycurcumin, bis-demethoxycurcumin, and ar-turmerone from Curcuma longa L. rhizomes on acetaminophen-induced hepatotoxicity in HepG2 cells

Objective: To assess the effects of turmeric extract and its compounds on oxidative stress, inflammation, and apoptosis in acetaminophen-induced liver injury. Methods: HepG2 cells were administered with acetaminophen (40 mM) to induce hepatotoxicity, followed by treatment with turmeric extract and i...

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Main Authors: Wahyu Widowati, Dian Ratih Laksmitawati, Diah Kartika Pratami, Deni Rahmat, S. Ravi Kiran, J. Achyutha Devi, Didik Priyandoko, Nindia Salsabila Mia Dewi, Annisa Firdaus Sutendi, Rizal Azis, Dhanar Septyawan Hadiprasetyo, Mariska Elizabeth
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2025-06-01
Series:Asian Pacific Journal of Tropical Biomedicine
Subjects:
acetaminophen
apoptosis
curcuma longa
curcumin
hepatotoxicity
inflammation
oxidative stress
Online Access:https://journals.lww.com/10.4103/apjtb.apjtb_770_24
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