Long-term conditions, multimorbidity and colorectal cancer risk in the UK Biobank cohort
Purpose Early identification of colorectal cancer (CRC) is an international priority. Multimorbidity (presence of ≥2 long-term conditions (LTCs)) is increasing and the relationship between CRC and LTCs is little-understood. This study explores the relationship between individual LTCs, multimorbidity...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-06-01
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| Series: | Journal of Multimorbidity and Comorbidity |
| Online Access: | https://doi.org/10.1177/26335565221110123 |
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| author | Neave ME Corcoran Frances S Mair Barbara Nicholl Sara Macdonald Bhautesh Dinesh Jani |
| author_facet | Neave ME Corcoran Frances S Mair Barbara Nicholl Sara Macdonald Bhautesh Dinesh Jani |
| author_sort | Neave ME Corcoran |
| collection | DOAJ |
| description | Purpose Early identification of colorectal cancer (CRC) is an international priority. Multimorbidity (presence of ≥2 long-term conditions (LTCs)) is increasing and the relationship between CRC and LTCs is little-understood. This study explores the relationship between individual LTCs, multimorbidity and CRC incidence and mortality. Methods Longitudinal analysis of the UK Biobank cohort, participants recruited 2006–2010; N = 500,195; excluding previous CRC at baseline. Baseline data was linked with cancer/mortality registers. Demographic characteristics, lifestyle factors, 43 LTCs, CRC family history, non-CRC cancers, and multimorbidity count were recorded. Variable selection models identified candidate LTCs potentially predictive of CRC outcomes and Cox regression models tested for significance of associations between selected LTCs and outcomes. Results Participants’ age range: 37–73 (mean age 56.5; 54.5% female). CRC was diagnosed in 3669 (0.73%) participants, and 916 (0.18%) died from CRC during follow-up (median follow-up 7 years). CRC incidence was higher in the presence of heart failure (Hazard Ratio (HR) 1.96, 95% Confidence Interval (CI) 1.13–3.40), diabetes (HR 1.15, CI 1.01–1.32), glaucoma (HR 1.36, CI 1.06–1.74), male cancers (HR 1.44, CI 1.01–2.08). CRC mortality was higher in presence of epilepsy (HR 1.83, CI 1.03–3.26), diabetes (HR 1.32, CI 1.02–1.72), osteoporosis (HR 1.67, CI 1.12–2.58). No significant association was found between multimorbidity (≥2 LTCs) and CRC outcomes. Conclusions The associations of certain LTCs with CRC incidence and mortality has implications for clinical practice: presence of certain LTCs in patients presenting with CRC symptoms could trigger early investigation and diagnosis. Future research should explore causative mechanisms and patient perspectives. |
| format | Article |
| id | doaj-art-b3bc98a04a134f88b47c54d8a7da3fff |
| institution | OA Journals |
| issn | 2633-5565 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Multimorbidity and Comorbidity |
| spelling | doaj-art-b3bc98a04a134f88b47c54d8a7da3fff2025-08-20T02:04:43ZengSAGE PublishingJournal of Multimorbidity and Comorbidity2633-55652022-06-011210.1177/26335565221110123Long-term conditions, multimorbidity and colorectal cancer risk in the UK Biobank cohortNeave ME CorcoranFrances S MairBarbara NichollSara MacdonaldBhautesh Dinesh JaniPurpose Early identification of colorectal cancer (CRC) is an international priority. Multimorbidity (presence of ≥2 long-term conditions (LTCs)) is increasing and the relationship between CRC and LTCs is little-understood. This study explores the relationship between individual LTCs, multimorbidity and CRC incidence and mortality. Methods Longitudinal analysis of the UK Biobank cohort, participants recruited 2006–2010; N = 500,195; excluding previous CRC at baseline. Baseline data was linked with cancer/mortality registers. Demographic characteristics, lifestyle factors, 43 LTCs, CRC family history, non-CRC cancers, and multimorbidity count were recorded. Variable selection models identified candidate LTCs potentially predictive of CRC outcomes and Cox regression models tested for significance of associations between selected LTCs and outcomes. Results Participants’ age range: 37–73 (mean age 56.5; 54.5% female). CRC was diagnosed in 3669 (0.73%) participants, and 916 (0.18%) died from CRC during follow-up (median follow-up 7 years). CRC incidence was higher in the presence of heart failure (Hazard Ratio (HR) 1.96, 95% Confidence Interval (CI) 1.13–3.40), diabetes (HR 1.15, CI 1.01–1.32), glaucoma (HR 1.36, CI 1.06–1.74), male cancers (HR 1.44, CI 1.01–2.08). CRC mortality was higher in presence of epilepsy (HR 1.83, CI 1.03–3.26), diabetes (HR 1.32, CI 1.02–1.72), osteoporosis (HR 1.67, CI 1.12–2.58). No significant association was found between multimorbidity (≥2 LTCs) and CRC outcomes. Conclusions The associations of certain LTCs with CRC incidence and mortality has implications for clinical practice: presence of certain LTCs in patients presenting with CRC symptoms could trigger early investigation and diagnosis. Future research should explore causative mechanisms and patient perspectives.https://doi.org/10.1177/26335565221110123 |
| spellingShingle | Neave ME Corcoran Frances S Mair Barbara Nicholl Sara Macdonald Bhautesh Dinesh Jani Long-term conditions, multimorbidity and colorectal cancer risk in the UK Biobank cohort Journal of Multimorbidity and Comorbidity |
| title | Long-term conditions, multimorbidity and colorectal cancer risk in the UK Biobank cohort |
| title_full | Long-term conditions, multimorbidity and colorectal cancer risk in the UK Biobank cohort |
| title_fullStr | Long-term conditions, multimorbidity and colorectal cancer risk in the UK Biobank cohort |
| title_full_unstemmed | Long-term conditions, multimorbidity and colorectal cancer risk in the UK Biobank cohort |
| title_short | Long-term conditions, multimorbidity and colorectal cancer risk in the UK Biobank cohort |
| title_sort | long term conditions multimorbidity and colorectal cancer risk in the uk biobank cohort |
| url | https://doi.org/10.1177/26335565221110123 |
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