Mycotic keratitis in India: a five-year retrospective study
Background: Mycotic keratitis is a fungal infection of the cornea. This infection is difficult to treat and it can lead to severe visual impairment or blindness. It is worldwide in distribution, but is more common in the tropics and subtropical regions. Trauma is the major predisposing factor, foll...
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The Journal of Infection in Developing Countries
2010-03-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/309 |
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| author | Ragini Tilak Abhisek Singh Om Prakash Singh Maurya Abhishek Chandra Vijai Tilak Anil Kumar Gulati |
| author_facet | Ragini Tilak Abhisek Singh Om Prakash Singh Maurya Abhishek Chandra Vijai Tilak Anil Kumar Gulati |
| author_sort | Ragini Tilak |
| collection | DOAJ |
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Background: Mycotic keratitis is a fungal infection of the cornea. This infection is difficult to treat and it can lead to severe visual impairment or blindness. It is worldwide in distribution, but is more common in the tropics and subtropical regions. Trauma is the major predisposing factor, followed by ocular and systemic defects, prior application of corticosteroids, and prolonged use of antibiotic eye-drops. The objective of this study was to determine causative agents and to identify the predisposing factors of mycotic keratitis.
Methodology: Corneal scrapings from 90 corneal ulcer patients with suspected fungal etiology were subjected to direct examination by 10% KOH mount, Gram stain and culture.
Results: This study included 90 subjects with corneal ulcers, based on clinical suspicion, of whom 41 cases were diagnosed with mycotic keratitis in the laboratory. Among these 41 cases, culture showed fungal growth only in 36 cases whereas the remaining five cases were positive only by potassium hydroxide (KOH) preparation. Males were more commonly affected and were mostly in the age group of 31-40 years. Aspergillus flavus was the most common fungus isolated followed by fusarium solani.
Conclusion: Rapid diagnosis and early institution of antifungal therapy is necessary to prevent ocular morbidity and blindness. Although culture helps in definite diagnosis and identification, direct microscopic detection of fungal structures in corneal scrapes or biopsies permits a rapid presumptive diagnosis.
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| format | Article |
| id | doaj-art-b3bc626a67f545a8827b326bde5772b7 |
| institution | Kabale University |
| issn | 1972-2680 |
| language | English |
| publishDate | 2010-03-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-b3bc626a67f545a8827b326bde5772b72025-08-20T03:48:58ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802010-03-0140310.3855/jidc.309Mycotic keratitis in India: a five-year retrospective studyRagini Tilak0Abhisek Singh1Om Prakash Singh Maurya2Abhishek Chandra3Vijai Tilak4Anil Kumar Gulati5Department of Microbiology, Institute of Medical Sciences, Banaras Hindu University, VaranasiDepartment of Ophthalmology, Institutes of Medical Sciences, Banaras Hindu University, VaranasiDepartment of Ophthalmology, Institutes of Medical Sciences, Banaras Hindu University, VaranasiDepartment of Ophthalmology, Institutes of Medical Sciences, Banaras Hindu University, VaranasiDepartment of Pathology, Institute of Medical Sciences, Banaras Hindu University, VaranasiDepartment of Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi Background: Mycotic keratitis is a fungal infection of the cornea. This infection is difficult to treat and it can lead to severe visual impairment or blindness. It is worldwide in distribution, but is more common in the tropics and subtropical regions. Trauma is the major predisposing factor, followed by ocular and systemic defects, prior application of corticosteroids, and prolonged use of antibiotic eye-drops. The objective of this study was to determine causative agents and to identify the predisposing factors of mycotic keratitis. Methodology: Corneal scrapings from 90 corneal ulcer patients with suspected fungal etiology were subjected to direct examination by 10% KOH mount, Gram stain and culture. Results: This study included 90 subjects with corneal ulcers, based on clinical suspicion, of whom 41 cases were diagnosed with mycotic keratitis in the laboratory. Among these 41 cases, culture showed fungal growth only in 36 cases whereas the remaining five cases were positive only by potassium hydroxide (KOH) preparation. Males were more commonly affected and were mostly in the age group of 31-40 years. Aspergillus flavus was the most common fungus isolated followed by fusarium solani. Conclusion: Rapid diagnosis and early institution of antifungal therapy is necessary to prevent ocular morbidity and blindness. Although culture helps in definite diagnosis and identification, direct microscopic detection of fungal structures in corneal scrapes or biopsies permits a rapid presumptive diagnosis. https://jidc.org/index.php/journal/article/view/309Corneal infectionsfungal keratitismycotic keratitisFusarium sp.Aspergillus sp. |
| spellingShingle | Ragini Tilak Abhisek Singh Om Prakash Singh Maurya Abhishek Chandra Vijai Tilak Anil Kumar Gulati Mycotic keratitis in India: a five-year retrospective study Journal of Infection in Developing Countries Corneal infections fungal keratitis mycotic keratitis Fusarium sp. Aspergillus sp. |
| title | Mycotic keratitis in India: a five-year retrospective study |
| title_full | Mycotic keratitis in India: a five-year retrospective study |
| title_fullStr | Mycotic keratitis in India: a five-year retrospective study |
| title_full_unstemmed | Mycotic keratitis in India: a five-year retrospective study |
| title_short | Mycotic keratitis in India: a five-year retrospective study |
| title_sort | mycotic keratitis in india a five year retrospective study |
| topic | Corneal infections fungal keratitis mycotic keratitis Fusarium sp. Aspergillus sp. |
| url | https://jidc.org/index.php/journal/article/view/309 |
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