Acute Myeloid Leukemia in an Infant with t(8;19)(p11.2;q13) Translocation: Case Report and a Review of the Literature
Acute myeloid leukemia (AML) patients with t(8;16)(p11.2;p13) constitute a small subgroup with a distinct genetic and clinical profile. We present a unique case of a female infant with monocytic AML associated with t(8;19)(p11.2;q13.3), a rarely reported variation of t(8;16)(p11.2;p13). The patient...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2019/4198415 |
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| author | Ashley C. Eason Silvia T. Bunting Jess F. Peterson Debra Saxe Himalee S. Sabnis |
| author_facet | Ashley C. Eason Silvia T. Bunting Jess F. Peterson Debra Saxe Himalee S. Sabnis |
| author_sort | Ashley C. Eason |
| collection | DOAJ |
| description | Acute myeloid leukemia (AML) patients with t(8;16)(p11.2;p13) constitute a small subgroup with a distinct genetic and clinical profile. We present a unique case of a female infant with monocytic AML associated with t(8;19)(p11.2;q13.3), a rarely reported variation of t(8;16)(p11.2;p13). The patient presented with leukemia cutis and demonstrated erythrophagocytosis in the diagnostic bone marrow. She responded well to standard AML chemotherapy and is currently in remission. Here, we highlight her case as the youngest AML patient with t(8;19) described in the literature, discuss the significance and prognostic implications of this genetic variant, and review 8p11.2 fusion proteins in AML. |
| format | Article |
| id | doaj-art-b3b59d0c727d4a699580e98166ff8f64 |
| institution | OA Journals |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-b3b59d0c727d4a699580e98166ff8f642025-08-20T02:23:14ZengWileyCase Reports in Hematology2090-65602090-65792019-01-01201910.1155/2019/41984154198415Acute Myeloid Leukemia in an Infant with t(8;19)(p11.2;q13) Translocation: Case Report and a Review of the LiteratureAshley C. Eason0Silvia T. Bunting1Jess F. Peterson2Debra Saxe3Himalee S. Sabnis4Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta and Emory University, Atlanta, GA, USADepartment of Pathology, Children’s Healthcare of Atlanta, Atlanta, GA, USADepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USADepartment of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USADepartment of Pediatrics, Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta and Emory University, Atlanta, GA, USAAcute myeloid leukemia (AML) patients with t(8;16)(p11.2;p13) constitute a small subgroup with a distinct genetic and clinical profile. We present a unique case of a female infant with monocytic AML associated with t(8;19)(p11.2;q13.3), a rarely reported variation of t(8;16)(p11.2;p13). The patient presented with leukemia cutis and demonstrated erythrophagocytosis in the diagnostic bone marrow. She responded well to standard AML chemotherapy and is currently in remission. Here, we highlight her case as the youngest AML patient with t(8;19) described in the literature, discuss the significance and prognostic implications of this genetic variant, and review 8p11.2 fusion proteins in AML.http://dx.doi.org/10.1155/2019/4198415 |
| spellingShingle | Ashley C. Eason Silvia T. Bunting Jess F. Peterson Debra Saxe Himalee S. Sabnis Acute Myeloid Leukemia in an Infant with t(8;19)(p11.2;q13) Translocation: Case Report and a Review of the Literature Case Reports in Hematology |
| title | Acute Myeloid Leukemia in an Infant with t(8;19)(p11.2;q13) Translocation: Case Report and a Review of the Literature |
| title_full | Acute Myeloid Leukemia in an Infant with t(8;19)(p11.2;q13) Translocation: Case Report and a Review of the Literature |
| title_fullStr | Acute Myeloid Leukemia in an Infant with t(8;19)(p11.2;q13) Translocation: Case Report and a Review of the Literature |
| title_full_unstemmed | Acute Myeloid Leukemia in an Infant with t(8;19)(p11.2;q13) Translocation: Case Report and a Review of the Literature |
| title_short | Acute Myeloid Leukemia in an Infant with t(8;19)(p11.2;q13) Translocation: Case Report and a Review of the Literature |
| title_sort | acute myeloid leukemia in an infant with t 8 19 p11 2 q13 translocation case report and a review of the literature |
| url | http://dx.doi.org/10.1155/2019/4198415 |
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