ZnPc photosensitizer-loaded peony-shaped FeSe 2 remotely controlled by near-infrared light for antimycobacterial therapy
The development of novel antimicrobial agents is highly desirable for treating bacterial infections. Here, a smart photodynamic therapy (PDT) system based on a combination of peony-shaped ferroselite FeSe 2 particles and zinc (II) phthalocyanine (ZnPc) photosensitizers was constructed. Effective en...
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| Format: | Article |
| Language: | English |
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Compuscript Ltd
2023-05-01
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| Series: | Acta Materia Medica |
| Online Access: | https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2023-0012 |
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| author | Peng Wu Xiaoning Liu Yuheng Duan Liping Pan Zhaogang Sun Hongqian Chu Chuanzhi Zhu Bei Liu |
| author_facet | Peng Wu Xiaoning Liu Yuheng Duan Liping Pan Zhaogang Sun Hongqian Chu Chuanzhi Zhu Bei Liu |
| author_sort | Peng Wu |
| collection | DOAJ |
| description | The development of novel antimicrobial agents is highly desirable for treating bacterial infections. Here, a smart photodynamic therapy (PDT) system based on a combination of peony-shaped ferroselite FeSe 2 particles and zinc (II) phthalocyanine (ZnPc) photosensitizers was constructed. Effective energy transfer occurred from ZnPc to FeSe 2 , because of their proximity, thus eliciting the OFF state of ZnPc photosensitizers. Under 808 nm NIR light irradiation, the photothermal effect of FeSe 2 promoted the release of ZnPc, thus turning on the photodynamic effect of the photosensitizers (ON state). In vitro, FeSe 2 -ZnPc exhibited high photo-to-thermal conversion efficiency (26.4%) and effective generation of reactive oxygen species for combined photothermal/photodynamic therapy. Therefore, the FeSe 2 -ZnPc hybrids have great potential to serve as alternatives to antibiotics for eradication of pathogenic bacteria. |
| format | Article |
| id | doaj-art-b3b3882cd8854ff5affc3023332a91e3 |
| institution | Kabale University |
| issn | 2737-7946 |
| language | English |
| publishDate | 2023-05-01 |
| publisher | Compuscript Ltd |
| record_format | Article |
| series | Acta Materia Medica |
| spelling | doaj-art-b3b3882cd8854ff5affc3023332a91e32025-08-20T03:28:05ZengCompuscript LtdActa Materia Medica2737-79462023-05-012226026910.15212/AMM-2023-0012ZnPc photosensitizer-loaded peony-shaped FeSe 2 remotely controlled by near-infrared light for antimycobacterial therapyPeng WuXiaoning LiuYuheng DuanLiping PanZhaogang SunHongqian ChuChuanzhi ZhuBei LiuThe development of novel antimicrobial agents is highly desirable for treating bacterial infections. Here, a smart photodynamic therapy (PDT) system based on a combination of peony-shaped ferroselite FeSe 2 particles and zinc (II) phthalocyanine (ZnPc) photosensitizers was constructed. Effective energy transfer occurred from ZnPc to FeSe 2 , because of their proximity, thus eliciting the OFF state of ZnPc photosensitizers. Under 808 nm NIR light irradiation, the photothermal effect of FeSe 2 promoted the release of ZnPc, thus turning on the photodynamic effect of the photosensitizers (ON state). In vitro, FeSe 2 -ZnPc exhibited high photo-to-thermal conversion efficiency (26.4%) and effective generation of reactive oxygen species for combined photothermal/photodynamic therapy. Therefore, the FeSe 2 -ZnPc hybrids have great potential to serve as alternatives to antibiotics for eradication of pathogenic bacteria.https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2023-0012 |
| spellingShingle | Peng Wu Xiaoning Liu Yuheng Duan Liping Pan Zhaogang Sun Hongqian Chu Chuanzhi Zhu Bei Liu ZnPc photosensitizer-loaded peony-shaped FeSe 2 remotely controlled by near-infrared light for antimycobacterial therapy Acta Materia Medica |
| title | ZnPc photosensitizer-loaded peony-shaped FeSe 2 remotely controlled by near-infrared light for antimycobacterial therapy |
| title_full | ZnPc photosensitizer-loaded peony-shaped FeSe 2 remotely controlled by near-infrared light for antimycobacterial therapy |
| title_fullStr | ZnPc photosensitizer-loaded peony-shaped FeSe 2 remotely controlled by near-infrared light for antimycobacterial therapy |
| title_full_unstemmed | ZnPc photosensitizer-loaded peony-shaped FeSe 2 remotely controlled by near-infrared light for antimycobacterial therapy |
| title_short | ZnPc photosensitizer-loaded peony-shaped FeSe 2 remotely controlled by near-infrared light for antimycobacterial therapy |
| title_sort | znpc photosensitizer loaded peony shaped fese 2 remotely controlled by near infrared light for antimycobacterial therapy |
| url | https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2023-0012 |
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