IgG promotes TNF‐α induced osteoclastogenesis by upregulating the expression of TNFR1 and the NF‐κB signalling pathway

IgG promotes TNF‐α induced osteoclastogenesis by upregulating the expression of TNFR1 and the NF‐κB signalling pathway

Abstract Objectives Tumor necrosis factor‐α (TNF‐α) plays a pivotal role in bone damage associated with inflammatory arthritis such as rheumatoid arthritis (RA). Both systemic lupus erythematosus (SLE) and rheumatoid arthritis exhibit clinical manifestations of inflammatory arthritis, yet the joint...

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Bibliographic Details
Main Authors: Haifeng Yin, Yao Teng, Guo‐Min Deng
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Clinical & Translational Immunology
Subjects:
Normal IgG
osteoclastogenesis
TNFR1
TNF‐α
Online Access:https://doi.org/10.1002/cti2.70034
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