Association between higher dietary lycopene intake and reduced depression risk among American adults: evidence from NHANES 2007–2016
IntroductionAlthough previous researches have suggested that certain dietary nutrients, such as carotenoids, have an effect on depression, epidemiological evidence on the relationship between lycopene and depression remains limited. This study aimed to investigate the association between dietary lyc...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1538396/full |
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| author | Xiaosong Li Yuru Lan |
| author_facet | Xiaosong Li Yuru Lan |
| author_sort | Xiaosong Li |
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| description | IntroductionAlthough previous researches have suggested that certain dietary nutrients, such as carotenoids, have an effect on depression, epidemiological evidence on the relationship between lycopene and depression remains limited. This study aimed to investigate the association between dietary lycopene intake and depression risk in American adults.MethodsData from 18,664 participants in the National Health and Nutrition Examination Survey (NHANES, 2007–2016) were analyzed, with depression defined by a nine-item Patient Health Questionnaire (PHQ-9) score ≥ 10. Dietary lycopene intake was estimated from the mean of two 24-h dietary recalls. Binary logistic regression and restricted cubic spline (RCS) models were employed to assess the relationship.ResultsDepression prevalence was 8.98%, and adjusted analyses indicated that higher dietary lycopene intake was significantly associated with a reduced depression risk compared to the lowest quartile (ORs for the second, third, and fourth quartiles: 0.851 [95% CI, 0.737–0.982], 0.829 [95% CI, 0.716–0.960], and 0.807 [95% CI, 0.695–0.938], respectively). Additionally, a U-shaped relationship was observed, with a reduction in depression risk associated with dietary lycopene intake ranging from 0 to 10,072 μg/d (P-non-linear = 0.017).DiscussionThis study suggested that higher dietary lycopene intake may confer a protective effect against depression in American adults. |
| format | Article |
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| language | English |
| publishDate | 2025-04-01 |
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| spelling | doaj-art-b3b2bc2d008d47e2a611e5434fa851c82025-08-20T02:16:56ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-04-011210.3389/fnut.2025.15383961538396Association between higher dietary lycopene intake and reduced depression risk among American adults: evidence from NHANES 2007–2016Xiaosong Li0Yuru Lan1School of Public Health, Wuhan University, Wuhan, ChinaDivision of Oncology, Department of Pediatric Surgery, West China Hospital of Sichuan University, Chengdu, ChinaIntroductionAlthough previous researches have suggested that certain dietary nutrients, such as carotenoids, have an effect on depression, epidemiological evidence on the relationship between lycopene and depression remains limited. This study aimed to investigate the association between dietary lycopene intake and depression risk in American adults.MethodsData from 18,664 participants in the National Health and Nutrition Examination Survey (NHANES, 2007–2016) were analyzed, with depression defined by a nine-item Patient Health Questionnaire (PHQ-9) score ≥ 10. Dietary lycopene intake was estimated from the mean of two 24-h dietary recalls. Binary logistic regression and restricted cubic spline (RCS) models were employed to assess the relationship.ResultsDepression prevalence was 8.98%, and adjusted analyses indicated that higher dietary lycopene intake was significantly associated with a reduced depression risk compared to the lowest quartile (ORs for the second, third, and fourth quartiles: 0.851 [95% CI, 0.737–0.982], 0.829 [95% CI, 0.716–0.960], and 0.807 [95% CI, 0.695–0.938], respectively). Additionally, a U-shaped relationship was observed, with a reduction in depression risk associated with dietary lycopene intake ranging from 0 to 10,072 μg/d (P-non-linear = 0.017).DiscussionThis study suggested that higher dietary lycopene intake may confer a protective effect against depression in American adults.https://www.frontiersin.org/articles/10.3389/fnut.2025.1538396/fulldietary lycopene intakedepressionNHANESdietlifestyle |
| spellingShingle | Xiaosong Li Yuru Lan Association between higher dietary lycopene intake and reduced depression risk among American adults: evidence from NHANES 2007–2016 Frontiers in Nutrition dietary lycopene intake depression NHANES diet lifestyle |
| title | Association between higher dietary lycopene intake and reduced depression risk among American adults: evidence from NHANES 2007–2016 |
| title_full | Association between higher dietary lycopene intake and reduced depression risk among American adults: evidence from NHANES 2007–2016 |
| title_fullStr | Association between higher dietary lycopene intake and reduced depression risk among American adults: evidence from NHANES 2007–2016 |
| title_full_unstemmed | Association between higher dietary lycopene intake and reduced depression risk among American adults: evidence from NHANES 2007–2016 |
| title_short | Association between higher dietary lycopene intake and reduced depression risk among American adults: evidence from NHANES 2007–2016 |
| title_sort | association between higher dietary lycopene intake and reduced depression risk among american adults evidence from nhanes 2007 2016 |
| topic | dietary lycopene intake depression NHANES diet lifestyle |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1538396/full |
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