O-GlcNAcylation of glutaminase isoform KGA inhibits ferroptosis through activation of glutaminolysis in hepatoblastoma

O-GlcNAcylation of glutaminase isoform KGA inhibits ferroptosis through activation of glutaminolysis in hepatoblastoma

Abstract Hepatoblastoma (HB), the most common pediatric hepatic malignancy, exhibits an increasing incidence. Metabolism reprogramming represents a pivotal hallmark in the oncogenic transformation process, with glutamine emerging as a critical energy source for neoplastic cells, rivaling glucose. Ho...

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Main Authors: Sijia Fang, Guoqing Zhu, Yi Xie, Miao Ding, Ni Zhen, Jiabei Zhu, Siwei Mao, Xiaochen Tang, Han Wu, Qi Zhang, Aijia Zhang, Xin Ni, Qiuhui Pan, Ji Ma
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02464-2
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