Antioxidant and Apoptotic Effect of Edaravone on Cisplatin-Induced Brain Injury in Rats
Purpose: This study aims to investigate the effect of edaravone in preventing cisplatin-induced brain damage. Methods: Forty female Wistar albino rats were included in the study. 4 groups were created. In group 1 (control group) (n=10), neither any drugs were given nor anything was performed. Group...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Acta Neurologica Taiwanica |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103//ANT.33-1_111_0067 |
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| Summary: | Purpose:
This study aims to investigate the effect of edaravone in preventing cisplatin-induced brain damage.
Methods:
Forty female Wistar albino rats were included in the study. 4 groups were created. In group 1 (control group) (n=10), neither any drugs were given nor anything was performed. Group 2 (cisplatin group) (n=10), single dose 7.5 mg/kg cisplatin was given. In group 3 (edaravone group) (n=10), single dose 1 mg/kg edaravone was administered. Group 4 (cisplatin+ edaravone group) (n=10), single dose 7.5 mg/kg cisplatin and 1 mg/kg edaravone were given. Brain tissue was removed in all rats after 3 days. Blood samples taken from heart tissue were examined for malondialdehyde (MDA) and nitric oxide (NO) levels. Brain tissue was evaluated for damage with p53, GFAP and Ki 67.
Results:
Edaravone reduced cisplatin-induced brain damage. MDA and NO levels in the cisplatin group were significantly higher than the other groups (p< 0.05). Likewise, tissue damage in the cisplatin group was significantly higher than in the other groups (p< 0.05). The immunohistochemical staining which was done by using p53, GFAP and Ki 67 was shown that tissue damage was higher in cisplatin group than cisplatin+ edaravone group and this difference was found to be statistically significant (p< 0.05).
Conclusion:
The findings of our study suggest that edaravone therapy may be effective in the prevention and treatment of cisplatin-induced brain injury. |
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| ISSN: | 1028-768X |