Elective single blastocyst transfer can achieve acceptable clinical pregnancy and live birth rates compared with elective double cleavage-stage embryo transfer in fresh cycles
Abstract Background To evaluate the effect of elective single blastocyst transfer (eSBT) and elective double cleavage-stage embryo transfer (eDET) on clinical pregnancy and live birth rates in fresh cycles. Methods This retrospective study analyzed a total of 2941 fresh transfer cycles, including 15...
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BMC
2025-07-01
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| Series: | BMC Pregnancy and Childbirth |
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| Online Access: | https://doi.org/10.1186/s12884-025-07768-w |
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| author | Linjun Chen Yue Ji Lihua Zhu Fei Lin Junshun Fang Jie Wang Shanshan Wang |
| author_facet | Linjun Chen Yue Ji Lihua Zhu Fei Lin Junshun Fang Jie Wang Shanshan Wang |
| author_sort | Linjun Chen |
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| description | Abstract Background To evaluate the effect of elective single blastocyst transfer (eSBT) and elective double cleavage-stage embryo transfer (eDET) on clinical pregnancy and live birth rates in fresh cycles. Methods This retrospective study analyzed a total of 2941 fresh transfer cycles, including 1548 eSBT cycles and 1393 eDET cycles. Clinical pregnancy, twin pregnancy and live birth rates of the two groups were compared. Results Overall, the rates of clinical pregnancy and live birth in the eDET group were significantly higher than those in the eSBT group (75.1% vs. 71.3%, P = 0.019; 66.6% vs. 63.0%, P = 0.039). It was shown that eDET lifted the rates of clinical pregnancy and live birth for patients aged less than 35 years (aOR 1.783, 95% CI 1.451–2.191; aOR 1.508, 95% CI 1.262–1.803) but not for patients age 35 years and over (aOR 0.874, 95% CI 0.538–1.421; aOR 1.036, 95% CI 0.638–1.682). The twin pregnancy rate in the eSBT group was significantly lower than that in the eDET group at all ages (aOR 32.116, 95% CI 21.758–47.404; aOR 14.325, 95% CI 5.449–37.657). Conclusion Compared with eDET, eSBT achieves clinically acceptable pregnancy and live birth rates while drastically reducing the risk of twin pregnancy in fresh cycles. It is generally recommended that infertile couples undergo eSBT during fresh cycles when possible, especially for females aged 35 years and over. |
| format | Article |
| id | doaj-art-b3a6574892c149de808cc3dd385b043e |
| institution | Kabale University |
| issn | 1471-2393 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
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| series | BMC Pregnancy and Childbirth |
| spelling | doaj-art-b3a6574892c149de808cc3dd385b043e2025-08-20T03:42:02ZengBMCBMC Pregnancy and Childbirth1471-23932025-07-012511910.1186/s12884-025-07768-wElective single blastocyst transfer can achieve acceptable clinical pregnancy and live birth rates compared with elective double cleavage-stage embryo transfer in fresh cyclesLinjun Chen0Yue Ji1Lihua Zhu2Fei Lin3Junshun Fang4Jie Wang5Shanshan Wang6Center for Reproductive Medicine and Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing UniversityCenter for Reproductive Medicine and Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing UniversityCenter for Reproductive Medicine and Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing UniversityCenter for Reproductive Medicine and Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing UniversityCenter for Reproductive Medicine and Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing UniversityCenter for Reproductive Medicine and Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing UniversityCenter for Reproductive Medicine and Obstetrics and Gynecology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing UniversityAbstract Background To evaluate the effect of elective single blastocyst transfer (eSBT) and elective double cleavage-stage embryo transfer (eDET) on clinical pregnancy and live birth rates in fresh cycles. Methods This retrospective study analyzed a total of 2941 fresh transfer cycles, including 1548 eSBT cycles and 1393 eDET cycles. Clinical pregnancy, twin pregnancy and live birth rates of the two groups were compared. Results Overall, the rates of clinical pregnancy and live birth in the eDET group were significantly higher than those in the eSBT group (75.1% vs. 71.3%, P = 0.019; 66.6% vs. 63.0%, P = 0.039). It was shown that eDET lifted the rates of clinical pregnancy and live birth for patients aged less than 35 years (aOR 1.783, 95% CI 1.451–2.191; aOR 1.508, 95% CI 1.262–1.803) but not for patients age 35 years and over (aOR 0.874, 95% CI 0.538–1.421; aOR 1.036, 95% CI 0.638–1.682). The twin pregnancy rate in the eSBT group was significantly lower than that in the eDET group at all ages (aOR 32.116, 95% CI 21.758–47.404; aOR 14.325, 95% CI 5.449–37.657). Conclusion Compared with eDET, eSBT achieves clinically acceptable pregnancy and live birth rates while drastically reducing the risk of twin pregnancy in fresh cycles. It is generally recommended that infertile couples undergo eSBT during fresh cycles when possible, especially for females aged 35 years and over.https://doi.org/10.1186/s12884-025-07768-wElective single blastocyst transferElective double cleavage-stage embryo transferClinical pregnancyTwin pregnancyLive birth |
| spellingShingle | Linjun Chen Yue Ji Lihua Zhu Fei Lin Junshun Fang Jie Wang Shanshan Wang Elective single blastocyst transfer can achieve acceptable clinical pregnancy and live birth rates compared with elective double cleavage-stage embryo transfer in fresh cycles BMC Pregnancy and Childbirth Elective single blastocyst transfer Elective double cleavage-stage embryo transfer Clinical pregnancy Twin pregnancy Live birth |
| title | Elective single blastocyst transfer can achieve acceptable clinical pregnancy and live birth rates compared with elective double cleavage-stage embryo transfer in fresh cycles |
| title_full | Elective single blastocyst transfer can achieve acceptable clinical pregnancy and live birth rates compared with elective double cleavage-stage embryo transfer in fresh cycles |
| title_fullStr | Elective single blastocyst transfer can achieve acceptable clinical pregnancy and live birth rates compared with elective double cleavage-stage embryo transfer in fresh cycles |
| title_full_unstemmed | Elective single blastocyst transfer can achieve acceptable clinical pregnancy and live birth rates compared with elective double cleavage-stage embryo transfer in fresh cycles |
| title_short | Elective single blastocyst transfer can achieve acceptable clinical pregnancy and live birth rates compared with elective double cleavage-stage embryo transfer in fresh cycles |
| title_sort | elective single blastocyst transfer can achieve acceptable clinical pregnancy and live birth rates compared with elective double cleavage stage embryo transfer in fresh cycles |
| topic | Elective single blastocyst transfer Elective double cleavage-stage embryo transfer Clinical pregnancy Twin pregnancy Live birth |
| url | https://doi.org/10.1186/s12884-025-07768-w |
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