Radix Rehmanniae and Corni Fructus against Diabetic Nephropathy via AGE-RAGE Signaling Pathway
Background and Aims. Radix Rehmanniae and Corni Fructus (RC) have been widely applied to treat diabetic nephropathy (DN) for centuries. But the mechanism of how RC plays the therapeutic role against DN is unclear as yet. Methods. The information about RC was obtained from a public database. The acti...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2020/8358102 |
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| author | Jing Chen Yuping Chen Anmei Shu Jinfu Lu Qiu Du Yuwei Yang Zhiyang Lv Huiqin Xu |
| author_facet | Jing Chen Yuping Chen Anmei Shu Jinfu Lu Qiu Du Yuwei Yang Zhiyang Lv Huiqin Xu |
| author_sort | Jing Chen |
| collection | DOAJ |
| description | Background and Aims. Radix Rehmanniae and Corni Fructus (RC) have been widely applied to treat diabetic nephropathy (DN) for centuries. But the mechanism of how RC plays the therapeutic role against DN is unclear as yet. Methods. The information about RC was obtained from a public database. The active compounds of RC were screened by oral bioavailability (OB) and drug-likeness (DL). Gene ontology (GO) analysis was performed to realize the key targets of RC, and an active compound-potential target network was created. The therapeutic effects of RC active compounds and their key signal pathways were preliminarily probed via network pharmacology analysis and animal experiments. Results. In this study, 29 active compounds from RC and 64 key targets related to DN were collected using the network pharmacology method. The pathway enrichment analysis showed that RC regulated advanced glycosylation end product (AGE-) RAGE and IL-17 signaling pathways to treat DN. The animal experiments revealed that RC significantly improved metabolic parameters, inflammation renal structure, and function to protect the kidney against DN. Conclusions. The results revealed the relationship between multicomponents and multitargets of RC. The administratiom of RC might remit the DM-induced renal damage through the AGE-RAGE signaling pathway to improve metabolic parameters and protect renal structure and function. |
| format | Article |
| id | doaj-art-b39f40068bfe4c1ebb88d9d378a26b4e |
| institution | DOAJ |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-b39f40068bfe4c1ebb88d9d378a26b4e2025-08-20T03:20:51ZengWileyJournal of Diabetes Research2314-67452314-67532020-01-01202010.1155/2020/83581028358102Radix Rehmanniae and Corni Fructus against Diabetic Nephropathy via AGE-RAGE Signaling PathwayJing Chen0Yuping Chen1Anmei Shu2Jinfu Lu3Qiu Du4Yuwei Yang5Zhiyang Lv6Huiqin Xu7Hanlin College, Nanjing University of Chinese Medicine, Taizhou 225300, ChinaDepartment of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, ChinaDepartment of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, ChinaDepartment of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, ChinaDepartment of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, ChinaHanlin College, Nanjing University of Chinese Medicine, Taizhou 225300, ChinaHanlin College, Nanjing University of Chinese Medicine, Taizhou 225300, ChinaDepartment of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, ChinaBackground and Aims. Radix Rehmanniae and Corni Fructus (RC) have been widely applied to treat diabetic nephropathy (DN) for centuries. But the mechanism of how RC plays the therapeutic role against DN is unclear as yet. Methods. The information about RC was obtained from a public database. The active compounds of RC were screened by oral bioavailability (OB) and drug-likeness (DL). Gene ontology (GO) analysis was performed to realize the key targets of RC, and an active compound-potential target network was created. The therapeutic effects of RC active compounds and their key signal pathways were preliminarily probed via network pharmacology analysis and animal experiments. Results. In this study, 29 active compounds from RC and 64 key targets related to DN were collected using the network pharmacology method. The pathway enrichment analysis showed that RC regulated advanced glycosylation end product (AGE-) RAGE and IL-17 signaling pathways to treat DN. The animal experiments revealed that RC significantly improved metabolic parameters, inflammation renal structure, and function to protect the kidney against DN. Conclusions. The results revealed the relationship between multicomponents and multitargets of RC. The administratiom of RC might remit the DM-induced renal damage through the AGE-RAGE signaling pathway to improve metabolic parameters and protect renal structure and function.http://dx.doi.org/10.1155/2020/8358102 |
| spellingShingle | Jing Chen Yuping Chen Anmei Shu Jinfu Lu Qiu Du Yuwei Yang Zhiyang Lv Huiqin Xu Radix Rehmanniae and Corni Fructus against Diabetic Nephropathy via AGE-RAGE Signaling Pathway Journal of Diabetes Research |
| title | Radix Rehmanniae and Corni Fructus against Diabetic Nephropathy via AGE-RAGE Signaling Pathway |
| title_full | Radix Rehmanniae and Corni Fructus against Diabetic Nephropathy via AGE-RAGE Signaling Pathway |
| title_fullStr | Radix Rehmanniae and Corni Fructus against Diabetic Nephropathy via AGE-RAGE Signaling Pathway |
| title_full_unstemmed | Radix Rehmanniae and Corni Fructus against Diabetic Nephropathy via AGE-RAGE Signaling Pathway |
| title_short | Radix Rehmanniae and Corni Fructus against Diabetic Nephropathy via AGE-RAGE Signaling Pathway |
| title_sort | radix rehmanniae and corni fructus against diabetic nephropathy via age rage signaling pathway |
| url | http://dx.doi.org/10.1155/2020/8358102 |
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