Research Progress in the Pathogenesis of Cognitive Dysfunction in White Matter Hyperintensities: A Narrative Review
Cerebral small vessel disease is a common disease endangering human health due to its insidious and repeated onset and progressive aggravation. White matter hyperintensities (WMHs) are one of the classic imaging markers of cerebral small vessel disease. The term ‘WMHs’ was first proposed by Hachinsk...
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IMR Press
2025-02-01
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| Series: | Journal of Integrative Neuroscience |
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| Online Access: | https://www.imrpress.com/journal/JIN/24/2/10.31083/JIN24840 |
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| author | Ni-Na Song Jing-Yuan Yu Chao Wang Xue-Qi Wu Guo-Zhao Ma Xiao-Ying Yuan Xu-Gang Wang |
| author_facet | Ni-Na Song Jing-Yuan Yu Chao Wang Xue-Qi Wu Guo-Zhao Ma Xiao-Ying Yuan Xu-Gang Wang |
| author_sort | Ni-Na Song |
| collection | DOAJ |
| description | Cerebral small vessel disease is a common disease endangering human health due to its insidious and repeated onset and progressive aggravation. White matter hyperintensities (WMHs) are one of the classic imaging markers of cerebral small vessel disease. The term ‘WMHs’ was first proposed by Hachinski in 1987. The WMHs in our study mainly refer to cerebral white matter damage caused by various vascular factors, known as vascularized white matter hyperintensity. WMHs are significantly correlated with stroke, cognitive dysfunction, emotional disturbance, and gait abnormality, and have drawn widespread attention. This article reviews the research progress on the pathogenesis of cognitive dysfunction associated with WMHs and provides a theoretical reference for understanding the pathogenesis of WMHs and the early assessment of associated cognitive dysfunction. |
| format | Article |
| id | doaj-art-b39bef5e51e349abb495f0d971b4ea57 |
| institution | OA Journals |
| issn | 0219-6352 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Journal of Integrative Neuroscience |
| spelling | doaj-art-b39bef5e51e349abb495f0d971b4ea572025-08-20T02:10:38ZengIMR PressJournal of Integrative Neuroscience0219-63522025-02-012422484010.31083/JIN24840S0219-6352(24)00818-0Research Progress in the Pathogenesis of Cognitive Dysfunction in White Matter Hyperintensities: A Narrative ReviewNi-Na Song0Jing-Yuan Yu1Chao Wang2Xue-Qi Wu3Guo-Zhao Ma4Xiao-Ying Yuan5Xu-Gang Wang6Department of Neurology, The Second Affiliated Hospital of Dalian Medical University, 116027 Dalian, Liaoning, ChinaCollege of Basic Medicine, Dalian Medical University, 116044 Dalian, Liaoning, ChinaCollege of Basic Medicine, Dalian Medical University, 116044 Dalian, Liaoning, ChinaCollege of Basic Medicine, Dalian Medical University, 116044 Dalian, Liaoning, ChinaCollege of Basic Medicine, Dalian Medical University, 116044 Dalian, Liaoning, ChinaDepartment of Anatomy, College of Basic Medicine, Dalian Medical University, 16044 Dalian, Liaoning, ChinaDepartment of Neurology, The Second Affiliated Hospital of Dalian Medical University, 116027 Dalian, Liaoning, ChinaCerebral small vessel disease is a common disease endangering human health due to its insidious and repeated onset and progressive aggravation. White matter hyperintensities (WMHs) are one of the classic imaging markers of cerebral small vessel disease. The term ‘WMHs’ was first proposed by Hachinski in 1987. The WMHs in our study mainly refer to cerebral white matter damage caused by various vascular factors, known as vascularized white matter hyperintensity. WMHs are significantly correlated with stroke, cognitive dysfunction, emotional disturbance, and gait abnormality, and have drawn widespread attention. This article reviews the research progress on the pathogenesis of cognitive dysfunction associated with WMHs and provides a theoretical reference for understanding the pathogenesis of WMHs and the early assessment of associated cognitive dysfunction.https://www.imrpress.com/journal/JIN/24/2/10.31083/JIN24840cerebral small vessel diseasemagnetic resonance imaging (mri)quantitative mricognitioncognition disorders |
| spellingShingle | Ni-Na Song Jing-Yuan Yu Chao Wang Xue-Qi Wu Guo-Zhao Ma Xiao-Ying Yuan Xu-Gang Wang Research Progress in the Pathogenesis of Cognitive Dysfunction in White Matter Hyperintensities: A Narrative Review Journal of Integrative Neuroscience cerebral small vessel disease magnetic resonance imaging (mri) quantitative mri cognition cognition disorders |
| title | Research Progress in the Pathogenesis of Cognitive Dysfunction in White Matter Hyperintensities: A Narrative Review |
| title_full | Research Progress in the Pathogenesis of Cognitive Dysfunction in White Matter Hyperintensities: A Narrative Review |
| title_fullStr | Research Progress in the Pathogenesis of Cognitive Dysfunction in White Matter Hyperintensities: A Narrative Review |
| title_full_unstemmed | Research Progress in the Pathogenesis of Cognitive Dysfunction in White Matter Hyperintensities: A Narrative Review |
| title_short | Research Progress in the Pathogenesis of Cognitive Dysfunction in White Matter Hyperintensities: A Narrative Review |
| title_sort | research progress in the pathogenesis of cognitive dysfunction in white matter hyperintensities a narrative review |
| topic | cerebral small vessel disease magnetic resonance imaging (mri) quantitative mri cognition cognition disorders |
| url | https://www.imrpress.com/journal/JIN/24/2/10.31083/JIN24840 |
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