RNA editing deficiency models differential immunogenicity of pancreatic α- and β-cells

RNA editing deficiency models differential immunogenicity of pancreatic α- and β-cells

Objective: A longstanding question in type 1 diabetes (T1D) research pertains to the selective loss of β-cells whilst neighboring islet α-cells remain unharmed. We examined molecular mechanisms that may underly this differential vulnerability, by investigating the role of RNA editing, a cellular pro...

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Bibliographic Details
Main Authors: Shani Peleg, Liza Zamashanski, Jonathan Belin, Roy Novoselsky, Roni Cohen-Fultheim, Udi Ehud Knebel, Benjamin Glaser, Shalev Itzkovitz, Klaus H. Kaestner, Alvin C. Powers, Erez Y. Levanon, Agnes Klochendler, Yuval Dor
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Molecular Metabolism
Subjects:
RNA editing
Type 1 diabetes
β-cells
α-cells
Islet inflammation
Interferon response
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877825000900
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