Development of a novel amplicon based whole-genome sequencing framework for improved surveillance of Toscana virus

Abstract Toscana virus (TOSV), a Phlebovirus transmitted by sandflies, is a leading cause of aseptic meningitis in the Mediterranean region. Despite its clinical significance, underreporting and limited availability of complete genomic data hinder a thorough understanding of its genetic diversity an...

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Main Authors: Martina Brandolini, Ludovica Ingletto, Giorgio Dirani, Silvia Zannoli, Andreea Maria Lapusneanu, Massimiliano Guerra, Alessandra Mistral De Pascali, Davide Lelli, Francesco Defilippo, Antonio Lavazza, Mattia Calzolari, Michele Dottori, Laura Dionisi, Claudia Colosimo, Giulia Gatti, Anna Marzucco, Maria Sofia Montanari, Laura Grumiro, Monica Cricca, Alessandra Scagliarini, Vittorio Sambri
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08159-9
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author Martina Brandolini
Ludovica Ingletto
Giorgio Dirani
Silvia Zannoli
Andreea Maria Lapusneanu
Massimiliano Guerra
Alessandra Mistral De Pascali
Davide Lelli
Francesco Defilippo
Antonio Lavazza
Mattia Calzolari
Michele Dottori
Laura Dionisi
Claudia Colosimo
Giulia Gatti
Anna Marzucco
Maria Sofia Montanari
Laura Grumiro
Monica Cricca
Alessandra Scagliarini
Vittorio Sambri
author_facet Martina Brandolini
Ludovica Ingletto
Giorgio Dirani
Silvia Zannoli
Andreea Maria Lapusneanu
Massimiliano Guerra
Alessandra Mistral De Pascali
Davide Lelli
Francesco Defilippo
Antonio Lavazza
Mattia Calzolari
Michele Dottori
Laura Dionisi
Claudia Colosimo
Giulia Gatti
Anna Marzucco
Maria Sofia Montanari
Laura Grumiro
Monica Cricca
Alessandra Scagliarini
Vittorio Sambri
author_sort Martina Brandolini
collection DOAJ
description Abstract Toscana virus (TOSV), a Phlebovirus transmitted by sandflies, is a leading cause of aseptic meningitis in the Mediterranean region. Despite its clinical significance, underreporting and limited availability of complete genomic data hinder a thorough understanding of its genetic diversity and evolution. This study presents a novel amplicon-based whole-genome sequencing (WGS) method using Illumina library preparation kits and proprietary software to optimize workflows and enhance bioinformatic analyses. Primers targeting TOSV lineage A genomes were designed with PrimalScheme to generate 400 bp amplicons, incorporating degenerate bases to improve coverage. Library preparation utilized Illumina Microbial Amplicon Prep (iMAP) kits, followed by de novo assembly using BaseSpace DRAGEN Targeted Microbial software. The method’s sensitivity was tested on viral propagates at various RNA concentrations (104 to 10 copies/μL), demonstrating robust performance at concentrations above 102 copies/μL. Validation on high-titre viral propagates (n = 7), low-titre clinical samples (n = 15), and phlebotomine pools (n = 5) confirmed its reproducibility and ability to comprehensively cover coding regions. Cerebrospinal fluid samples yielded the most consistent results compared to urine and sandfly pools. This innovative WGS approach represents a significant advancement in TOSV genomic surveillance, enabling large-scale studies of its genetic diversity and evolutionary dynamics, which are critical for improving diagnostics and public health strategies.
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spelling doaj-art-b392821682c543b1a85d64bed89f3bc72025-08-20T03:09:19ZengNature PortfolioCommunications Biology2399-36422025-05-018111010.1038/s42003-025-08159-9Development of a novel amplicon based whole-genome sequencing framework for improved surveillance of Toscana virusMartina Brandolini0Ludovica Ingletto1Giorgio Dirani2Silvia Zannoli3Andreea Maria Lapusneanu4Massimiliano Guerra5Alessandra Mistral De Pascali6Davide Lelli7Francesco Defilippo8Antonio Lavazza9Mattia Calzolari10Michele Dottori11Laura Dionisi12Claudia Colosimo13Giulia Gatti14Anna Marzucco15Maria Sofia Montanari16Laura Grumiro17Monica Cricca18Alessandra Scagliarini19Vittorio Sambri20Unit of Microbiology, The Greater Romagna Area Hub LaboratoryDepartment of Medical and Surgical Sciences (DIMEC), University of BolognaUnit of Microbiology, The Greater Romagna Area Hub LaboratoryUnit of Microbiology, The Greater Romagna Area Hub LaboratoryUnit of Microbiology, The Greater Romagna Area Hub LaboratoryUnit of Microbiology, The Greater Romagna Area Hub LaboratoryUnit of Microbiology, The Greater Romagna Area Hub LaboratoryIstituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia-Romagna “Bruno Ubertini” (IZSLER)Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia-Romagna “Bruno Ubertini” (IZSLER)Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia-Romagna “Bruno Ubertini” (IZSLER)Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia-Romagna “Bruno Ubertini” (IZSLER)Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia-Romagna “Bruno Ubertini” (IZSLER)Department of Medical and Surgical Sciences (DIMEC), University of BolognaDepartment of Medical and Surgical Sciences (DIMEC), University of BolognaUnit of Microbiology, The Greater Romagna Area Hub LaboratoryUnit of Microbiology, The Greater Romagna Area Hub LaboratoryUnit of Microbiology, The Greater Romagna Area Hub LaboratoryUnit of Microbiology, The Greater Romagna Area Hub LaboratoryUnit of Microbiology, The Greater Romagna Area Hub LaboratoryDepartment of Medical and Surgical Sciences (DIMEC), University of BolognaUnit of Microbiology, The Greater Romagna Area Hub LaboratoryAbstract Toscana virus (TOSV), a Phlebovirus transmitted by sandflies, is a leading cause of aseptic meningitis in the Mediterranean region. Despite its clinical significance, underreporting and limited availability of complete genomic data hinder a thorough understanding of its genetic diversity and evolution. This study presents a novel amplicon-based whole-genome sequencing (WGS) method using Illumina library preparation kits and proprietary software to optimize workflows and enhance bioinformatic analyses. Primers targeting TOSV lineage A genomes were designed with PrimalScheme to generate 400 bp amplicons, incorporating degenerate bases to improve coverage. Library preparation utilized Illumina Microbial Amplicon Prep (iMAP) kits, followed by de novo assembly using BaseSpace DRAGEN Targeted Microbial software. The method’s sensitivity was tested on viral propagates at various RNA concentrations (104 to 10 copies/μL), demonstrating robust performance at concentrations above 102 copies/μL. Validation on high-titre viral propagates (n = 7), low-titre clinical samples (n = 15), and phlebotomine pools (n = 5) confirmed its reproducibility and ability to comprehensively cover coding regions. Cerebrospinal fluid samples yielded the most consistent results compared to urine and sandfly pools. This innovative WGS approach represents a significant advancement in TOSV genomic surveillance, enabling large-scale studies of its genetic diversity and evolutionary dynamics, which are critical for improving diagnostics and public health strategies.https://doi.org/10.1038/s42003-025-08159-9
spellingShingle Martina Brandolini
Ludovica Ingletto
Giorgio Dirani
Silvia Zannoli
Andreea Maria Lapusneanu
Massimiliano Guerra
Alessandra Mistral De Pascali
Davide Lelli
Francesco Defilippo
Antonio Lavazza
Mattia Calzolari
Michele Dottori
Laura Dionisi
Claudia Colosimo
Giulia Gatti
Anna Marzucco
Maria Sofia Montanari
Laura Grumiro
Monica Cricca
Alessandra Scagliarini
Vittorio Sambri
Development of a novel amplicon based whole-genome sequencing framework for improved surveillance of Toscana virus
Communications Biology
title Development of a novel amplicon based whole-genome sequencing framework for improved surveillance of Toscana virus
title_full Development of a novel amplicon based whole-genome sequencing framework for improved surveillance of Toscana virus
title_fullStr Development of a novel amplicon based whole-genome sequencing framework for improved surveillance of Toscana virus
title_full_unstemmed Development of a novel amplicon based whole-genome sequencing framework for improved surveillance of Toscana virus
title_short Development of a novel amplicon based whole-genome sequencing framework for improved surveillance of Toscana virus
title_sort development of a novel amplicon based whole genome sequencing framework for improved surveillance of toscana virus
url https://doi.org/10.1038/s42003-025-08159-9
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