Immuno-protective impact and clinical translation of radioprotective agents in cancer radiotherapy
Radiotherapy, as a key component of the comprehensive treatment system for malignant tumors, not only facilitates precise tumor destruction but also necessitates the strategic use of radioprotective agents to regulate immune responses and mitigate toxicity in normal tissues. Revealing the molecular...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1610296/full |
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| author | Yiyong Huang Xiaolan Lv Tao Si Xia Meng Xiaolin Liao Pengfei Zhang Zheng Peng Zheng Peng Zheyi Zhou Ping Yi Shigao Huang |
| author_facet | Yiyong Huang Xiaolan Lv Tao Si Xia Meng Xiaolin Liao Pengfei Zhang Zheng Peng Zheng Peng Zheyi Zhou Ping Yi Shigao Huang |
| author_sort | Yiyong Huang |
| collection | DOAJ |
| description | Radiotherapy, as a key component of the comprehensive treatment system for malignant tumors, not only facilitates precise tumor destruction but also necessitates the strategic use of radioprotective agents to regulate immune responses and mitigate toxicity in normal tissues. Revealing the molecular biological mechanisms of ionizing radiation damage, such as DNA double-strand breaks, oxidative stress responses, and abnormal cell cycle regulation is critical for the development of clinically effective radioprotective drugs. Such advancements hold dual significance in enhancing patient outcomes and improving clinical efficacy. This paper explores the classification of radioprotective agents, and their diverse mechanisms of action, including free radical scavenging, regulation of redox enzyme systems, suppression of ionizing radiation-induced inflammation, and apoptosis-related immune damage. And, it also examines the challenges and prospects of their clinical translation. This study aims to provide important theoretical framework for the development of radioprotective agents to contribute to future advancements in radiation therapy. |
| format | Article |
| id | doaj-art-b3891f8144674bb3af6e4ba874233f2d |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-b3891f8144674bb3af6e4ba874233f2d2025-08-20T03:29:11ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-07-011610.3389/fimmu.2025.16102961610296Immuno-protective impact and clinical translation of radioprotective agents in cancer radiotherapyYiyong Huang0Xiaolan Lv1Tao Si2Xia Meng3Xiaolin Liao4Pengfei Zhang5Zheng Peng6Zheng Peng7Zheyi Zhou8Ping Yi9Shigao Huang10Department of Clinical Laboratory, Liuzhou Traditional Chinese Medical Hospital, Liuzhou, Guangxi, ChinaDepartment of Clinical Laboratory, Liuzhou Maternity and Child Healthcare Hospital, Liuzhou, Guangxi, ChinaDepartment of Clinical Oncology, Liuzhou Traditional Chinese Medical Hospital, Liuzhou, Guangxi, ChinaDepartment of Clinical Laboratory, Liuzhou Traditional Chinese Medical Hospital, Liuzhou, Guangxi, ChinaDepartment of Orthopedics, Liuzhou Traditional Chinese Medical Hospital, Liuzhou, Guangxi, ChinaDepartment of Pulmonary and Critical Care Medicine, Liuzhou Traditional Chinese Medical Hospital, Liuzhou, Guangxi, ChinaDepartment of Clinical Laboratory, Liuzhou Traditional Chinese Medical Hospital, Liuzhou, Guangxi, ChinaPostdoctoral Research Workstation, Wuzhou Red Cross Hospital, Wuzhou, Guangxi, ChinaDepartment of Neurology, Liuzhou Traditional Chinese Medical Hospital, Liuzhou, Guangxi, ChinaDepartment of Gastroenterology, Liuzhou Traditional Chinese Medical Hospital, Liuzhou, Guangxi, ChinaDepartment of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi’an, ChinaRadiotherapy, as a key component of the comprehensive treatment system for malignant tumors, not only facilitates precise tumor destruction but also necessitates the strategic use of radioprotective agents to regulate immune responses and mitigate toxicity in normal tissues. Revealing the molecular biological mechanisms of ionizing radiation damage, such as DNA double-strand breaks, oxidative stress responses, and abnormal cell cycle regulation is critical for the development of clinically effective radioprotective drugs. Such advancements hold dual significance in enhancing patient outcomes and improving clinical efficacy. This paper explores the classification of radioprotective agents, and their diverse mechanisms of action, including free radical scavenging, regulation of redox enzyme systems, suppression of ionizing radiation-induced inflammation, and apoptosis-related immune damage. And, it also examines the challenges and prospects of their clinical translation. This study aims to provide important theoretical framework for the development of radioprotective agents to contribute to future advancements in radiation therapy.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1610296/fullradioprotectorprotective mechanismimmuno-protectiveclinical applicationcancer radiotherapy |
| spellingShingle | Yiyong Huang Xiaolan Lv Tao Si Xia Meng Xiaolin Liao Pengfei Zhang Zheng Peng Zheng Peng Zheyi Zhou Ping Yi Shigao Huang Immuno-protective impact and clinical translation of radioprotective agents in cancer radiotherapy Frontiers in Immunology radioprotector protective mechanism immuno-protective clinical application cancer radiotherapy |
| title | Immuno-protective impact and clinical translation of radioprotective agents in cancer radiotherapy |
| title_full | Immuno-protective impact and clinical translation of radioprotective agents in cancer radiotherapy |
| title_fullStr | Immuno-protective impact and clinical translation of radioprotective agents in cancer radiotherapy |
| title_full_unstemmed | Immuno-protective impact and clinical translation of radioprotective agents in cancer radiotherapy |
| title_short | Immuno-protective impact and clinical translation of radioprotective agents in cancer radiotherapy |
| title_sort | immuno protective impact and clinical translation of radioprotective agents in cancer radiotherapy |
| topic | radioprotector protective mechanism immuno-protective clinical application cancer radiotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1610296/full |
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