Distinct patterns of visuo-tactile and visuo-motor body-related integration in Parkinson’s disease
Abstract Multisensory integration (MSI) deficits in patients with Parkinson’s Disease (PD) have recently attracted growing interest in both clinical and research realms, MSI being crucial in maintaining well-coordinated responses to external stimuli. In this framework, we exploited the Rubber Hand I...
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Nature Portfolio
2025-07-01
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| Online Access: | https://doi.org/10.1038/s41598-025-08965-5 |
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| author | Francesca Genovese Marcella Romeo Francesco Paolo Terrenzio Nadia Esposito Cristina Destefanis Patrizia Gindri Francesca Garbarini Alice Rossi Sebastiano |
| author_facet | Francesca Genovese Marcella Romeo Francesco Paolo Terrenzio Nadia Esposito Cristina Destefanis Patrizia Gindri Francesca Garbarini Alice Rossi Sebastiano |
| author_sort | Francesca Genovese |
| collection | DOAJ |
| description | Abstract Multisensory integration (MSI) deficits in patients with Parkinson’s Disease (PD) have recently attracted growing interest in both clinical and research realms, MSI being crucial in maintaining well-coordinated responses to external stimuli. In this framework, we exploited the Rubber Hand Illusion (RHI), an experimental procedure that induces healthy individuals to embody a fake hand by integrating multisensory body-related cues, to address potential alterations of the embodiment phenomenon in PD. Specifically, we leveraged a visuo-tactile (VT; Experiment 1) and a visuo-motor (VM; Experiment 2) RHI version and applied it to 32 PD patients and age-matched controls. Classical RHI measures (i.e., ownership and agency questionnaires, proprioceptive drift) were collected. Questionnaires revealed typical VT- and VM-RHI patterns in patients, although diminished as compared to controls. Crucially, proprioceptive drift showed an abolishment of VM- (but not VT-) RHI effect in patients, advocating for a channel-specific embodiment abnormality that emerged only when the motor system, involved in the pathology, was challenged by the RHI. Interestingly, such a deficit emerged specifically when proprioceptive drift, engaging a motor response, was considered as a measure. We speculatively interpret this finding in light of the neural degeneration of basal ganglia in PD, being these structures engaged in visuo-motor integration. |
| format | Article |
| id | doaj-art-b38526262f5e404c882832ad3b137cdd |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
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| spelling | doaj-art-b38526262f5e404c882832ad3b137cdd2025-08-20T04:03:00ZengNature PortfolioScientific Reports2045-23222025-07-0115111310.1038/s41598-025-08965-5Distinct patterns of visuo-tactile and visuo-motor body-related integration in Parkinson’s diseaseFrancesca Genovese0Marcella Romeo1Francesco Paolo Terrenzio2Nadia Esposito3Cristina Destefanis4Patrizia Gindri5Francesca Garbarini6Alice Rossi Sebastiano7MANIBUS Lab, Department of Psychology, University of TurinMANIBUS Lab, Department of Psychology, University of TurinSan Camillo Hospital of TurinSan Camillo Hospital of TurinSan Camillo Hospital of TurinSan Camillo Hospital of TurinMANIBUS Lab, Department of Psychology, University of TurinMANIBUS Lab, Department of Psychology, University of TurinAbstract Multisensory integration (MSI) deficits in patients with Parkinson’s Disease (PD) have recently attracted growing interest in both clinical and research realms, MSI being crucial in maintaining well-coordinated responses to external stimuli. In this framework, we exploited the Rubber Hand Illusion (RHI), an experimental procedure that induces healthy individuals to embody a fake hand by integrating multisensory body-related cues, to address potential alterations of the embodiment phenomenon in PD. Specifically, we leveraged a visuo-tactile (VT; Experiment 1) and a visuo-motor (VM; Experiment 2) RHI version and applied it to 32 PD patients and age-matched controls. Classical RHI measures (i.e., ownership and agency questionnaires, proprioceptive drift) were collected. Questionnaires revealed typical VT- and VM-RHI patterns in patients, although diminished as compared to controls. Crucially, proprioceptive drift showed an abolishment of VM- (but not VT-) RHI effect in patients, advocating for a channel-specific embodiment abnormality that emerged only when the motor system, involved in the pathology, was challenged by the RHI. Interestingly, such a deficit emerged specifically when proprioceptive drift, engaging a motor response, was considered as a measure. We speculatively interpret this finding in light of the neural degeneration of basal ganglia in PD, being these structures engaged in visuo-motor integration.https://doi.org/10.1038/s41598-025-08965-5Multisensory integrationParkinson’s diseaseVisuo-tactileVisuo-motorRubber hand illusion |
| spellingShingle | Francesca Genovese Marcella Romeo Francesco Paolo Terrenzio Nadia Esposito Cristina Destefanis Patrizia Gindri Francesca Garbarini Alice Rossi Sebastiano Distinct patterns of visuo-tactile and visuo-motor body-related integration in Parkinson’s disease Scientific Reports Multisensory integration Parkinson’s disease Visuo-tactile Visuo-motor Rubber hand illusion |
| title | Distinct patterns of visuo-tactile and visuo-motor body-related integration in Parkinson’s disease |
| title_full | Distinct patterns of visuo-tactile and visuo-motor body-related integration in Parkinson’s disease |
| title_fullStr | Distinct patterns of visuo-tactile and visuo-motor body-related integration in Parkinson’s disease |
| title_full_unstemmed | Distinct patterns of visuo-tactile and visuo-motor body-related integration in Parkinson’s disease |
| title_short | Distinct patterns of visuo-tactile and visuo-motor body-related integration in Parkinson’s disease |
| title_sort | distinct patterns of visuo tactile and visuo motor body related integration in parkinson s disease |
| topic | Multisensory integration Parkinson’s disease Visuo-tactile Visuo-motor Rubber hand illusion |
| url | https://doi.org/10.1038/s41598-025-08965-5 |
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