RBM39 shapes innate immunity by controlling the expression of key factors of the interferon response

RBM39 shapes innate immunity by controlling the expression of key factors of the interferon response

Background and aimsThe contribution of innate immunity to clearance of viral infections of the liver, in particular sensing via Toll-like receptor 3 (TLR3), is incompletely understood. We aimed to identify the factors contributing to the TLR3 response in hepatocytes via CRISPR/Cas9 screening.Methods...

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Main Authors: Teng-Feng Li, Paul Rothhaar, Arthur Lang, Oliver Grünvogel, Ombretta Colasanti, Santa Mariela Olivera Ugarte, Jannik Traut, Antonio Piras, Nelson Acosta-Rivero, Vladimir Gonçalves Magalhães, Emely Springer, Andreas Betz, Hao-En Huang, Jeongbin Park, Ruiyue Qiu, Gnimah Eva Gnouamozi, Ann-Kathrin Mehnert, Viet Loan Dao Thi, Stephan Urban, Martina Muckenthaler, Matthias Schlesner, Dirk Wohlleber, Marco Binder, Ralf Bartenschlager, Andreas Pichlmair, Volker Lohmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
RBM39
IRF3
STAT1
STAT2
IFNs
splicing
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1568056/full
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