A Complex Interplay between Wnt/β-Catenin Signalling and the Cell Cycle in the Adult Liver
Canonical Wnt signalling, governed by its effector β-catenin, is known for a long time as playing an important role in development, tissue homeostasis, and cancer. In the liver, it was unravelled as both an oncogenic pathway involved in a subset of liver cancers and a physiological signalling identi...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2012/816125 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850159723385454592 |
|---|---|
| author | Angélique Gougelet Sabine Colnot |
| author_facet | Angélique Gougelet Sabine Colnot |
| author_sort | Angélique Gougelet |
| collection | DOAJ |
| description | Canonical Wnt signalling, governed by its effector β-catenin, is known for a long time as playing an important role in development, tissue homeostasis, and cancer. In the liver, it was unravelled as both an oncogenic pathway involved in a subset of liver cancers and a physiological signalling identified as the “zonation-keeper” of the quiescent liver lobule. This duality has encouraged to explore the role of canonical Wnt in liver regeneration and liver-cell proliferation mainly using murine genetic models of β-catenin overactivation or inactivation. These studies definitely integrate Wnt signalling within the hepatic network driving regeneration and proliferation. We will review here the current knowledge concerning the mitogenic effect of Wnt, to switch on its specific role in the liver, which is quiescent but with a great capacity to regenerate. The duality of β-catenin signalling, associated both with liver quiescence and liver-cell proliferation, will be brought forward. |
| format | Article |
| id | doaj-art-b382cd6ba0e444b5a97b29732f5a48d4 |
| institution | OA Journals |
| issn | 2090-3448 2090-3456 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-b382cd6ba0e444b5a97b29732f5a48d42025-08-20T02:23:26ZengWileyInternational Journal of Hepatology2090-34482090-34562012-01-01201210.1155/2012/816125816125A Complex Interplay between Wnt/β-Catenin Signalling and the Cell Cycle in the Adult LiverAngélique Gougelet0Sabine Colnot1INSERM, U1016, Institut Cochin, 75014 Paris, FranceINSERM, U1016, Institut Cochin, 75014 Paris, FranceCanonical Wnt signalling, governed by its effector β-catenin, is known for a long time as playing an important role in development, tissue homeostasis, and cancer. In the liver, it was unravelled as both an oncogenic pathway involved in a subset of liver cancers and a physiological signalling identified as the “zonation-keeper” of the quiescent liver lobule. This duality has encouraged to explore the role of canonical Wnt in liver regeneration and liver-cell proliferation mainly using murine genetic models of β-catenin overactivation or inactivation. These studies definitely integrate Wnt signalling within the hepatic network driving regeneration and proliferation. We will review here the current knowledge concerning the mitogenic effect of Wnt, to switch on its specific role in the liver, which is quiescent but with a great capacity to regenerate. The duality of β-catenin signalling, associated both with liver quiescence and liver-cell proliferation, will be brought forward.http://dx.doi.org/10.1155/2012/816125 |
| spellingShingle | Angélique Gougelet Sabine Colnot A Complex Interplay between Wnt/β-Catenin Signalling and the Cell Cycle in the Adult Liver International Journal of Hepatology |
| title | A Complex Interplay between Wnt/β-Catenin Signalling and the Cell Cycle in the Adult Liver |
| title_full | A Complex Interplay between Wnt/β-Catenin Signalling and the Cell Cycle in the Adult Liver |
| title_fullStr | A Complex Interplay between Wnt/β-Catenin Signalling and the Cell Cycle in the Adult Liver |
| title_full_unstemmed | A Complex Interplay between Wnt/β-Catenin Signalling and the Cell Cycle in the Adult Liver |
| title_short | A Complex Interplay between Wnt/β-Catenin Signalling and the Cell Cycle in the Adult Liver |
| title_sort | complex interplay between wnt β catenin signalling and the cell cycle in the adult liver |
| url | http://dx.doi.org/10.1155/2012/816125 |
| work_keys_str_mv | AT angeliquegougelet acomplexinterplaybetweenwntbcateninsignallingandthecellcycleintheadultliver AT sabinecolnot acomplexinterplaybetweenwntbcateninsignallingandthecellcycleintheadultliver AT angeliquegougelet complexinterplaybetweenwntbcateninsignallingandthecellcycleintheadultliver AT sabinecolnot complexinterplaybetweenwntbcateninsignallingandthecellcycleintheadultliver |