Synthesis, Characterization, and Physicochemical Studies of Mixed Ligand Complexes of Inner Transition Metals with Lansoprazole and Cytosine
Few complexes of inner transition metals [Th(IV), Ce(IV), Nd(III), Gd(III)] have been synthesized by reacting their metal salts with lansoprazole, 2-([3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl)-1H-benzoimidazole and cytosine. All the complexes were synthesized in ethanolic mediu...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2013/309179 |
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| author | Sarika Verma Sarita Shrivastva Rashmi Shrivastva |
| author_facet | Sarika Verma Sarita Shrivastva Rashmi Shrivastva |
| author_sort | Sarika Verma |
| collection | DOAJ |
| description | Few complexes of inner transition metals [Th(IV), Ce(IV), Nd(III), Gd(III)] have been synthesized by reacting their metal salts with lansoprazole, 2-([3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl)-1H-benzoimidazole and cytosine. All the complexes were synthesized in ethanolic medium. The yield percentage rangs from 80 to 90%. The complexes are coloured solids. The complexes were characterized through elemental analyses, conductance measurements, and spectroscopic methods (FT IR, FAB Mass, 1H NMR and UV). An IR spectrum indicates that the ligand behaves as bidentate ligands. The metal complexes have been screened for their antifungal activity towards Aspergillus niger fungi. The interaction of inner transition metals with lansoprazole, in presence of cytosine, has also been investigated potentiometrically at two different temperatures 26±1°C and 36±1°C and at 0.1 M (KNO3) ionic strength. The stability constants of ternary complexes indicate the stability order as Th(IV) < Ce(IV) < Gd(III) < Nd(III). logK values obtained are positive and suggest greater stabilization of ternary complexes. The values of thermodynamic parameters (free energy (ΔG), enthalpy (ΔH), and entropy (ΔS) are also calculated. |
| format | Article |
| id | doaj-art-b3794e733a68447f8ecb6a38553be834 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-b3794e733a68447f8ecb6a38553be8342025-02-03T06:11:41ZengWileyJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/309179309179Synthesis, Characterization, and Physicochemical Studies of Mixed Ligand Complexes of Inner Transition Metals with Lansoprazole and CytosineSarika Verma0Sarita Shrivastva1Rashmi Shrivastva2Chemical Laboratory, Government Motilal Vigyan Mahavidhalaya, Bhopal, IndiaChemical Laboratory, Government Motilal Vigyan Mahavidhalaya, Bhopal, IndiaChemical Laboratory, Government Motilal Vigyan Mahavidhalaya, Bhopal, IndiaFew complexes of inner transition metals [Th(IV), Ce(IV), Nd(III), Gd(III)] have been synthesized by reacting their metal salts with lansoprazole, 2-([3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl)-1H-benzoimidazole and cytosine. All the complexes were synthesized in ethanolic medium. The yield percentage rangs from 80 to 90%. The complexes are coloured solids. The complexes were characterized through elemental analyses, conductance measurements, and spectroscopic methods (FT IR, FAB Mass, 1H NMR and UV). An IR spectrum indicates that the ligand behaves as bidentate ligands. The metal complexes have been screened for their antifungal activity towards Aspergillus niger fungi. The interaction of inner transition metals with lansoprazole, in presence of cytosine, has also been investigated potentiometrically at two different temperatures 26±1°C and 36±1°C and at 0.1 M (KNO3) ionic strength. The stability constants of ternary complexes indicate the stability order as Th(IV) < Ce(IV) < Gd(III) < Nd(III). logK values obtained are positive and suggest greater stabilization of ternary complexes. The values of thermodynamic parameters (free energy (ΔG), enthalpy (ΔH), and entropy (ΔS) are also calculated.http://dx.doi.org/10.1155/2013/309179 |
| spellingShingle | Sarika Verma Sarita Shrivastva Rashmi Shrivastva Synthesis, Characterization, and Physicochemical Studies of Mixed Ligand Complexes of Inner Transition Metals with Lansoprazole and Cytosine Journal of Chemistry |
| title | Synthesis, Characterization, and Physicochemical Studies of Mixed Ligand Complexes of Inner Transition Metals with Lansoprazole and Cytosine |
| title_full | Synthesis, Characterization, and Physicochemical Studies of Mixed Ligand Complexes of Inner Transition Metals with Lansoprazole and Cytosine |
| title_fullStr | Synthesis, Characterization, and Physicochemical Studies of Mixed Ligand Complexes of Inner Transition Metals with Lansoprazole and Cytosine |
| title_full_unstemmed | Synthesis, Characterization, and Physicochemical Studies of Mixed Ligand Complexes of Inner Transition Metals with Lansoprazole and Cytosine |
| title_short | Synthesis, Characterization, and Physicochemical Studies of Mixed Ligand Complexes of Inner Transition Metals with Lansoprazole and Cytosine |
| title_sort | synthesis characterization and physicochemical studies of mixed ligand complexes of inner transition metals with lansoprazole and cytosine |
| url | http://dx.doi.org/10.1155/2013/309179 |
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