Anti-sense oligonucleotide probing as a structural platform for studying ribonucleoprotein complex assembly

Abstract Investigating the intricate and rapid folding kinetics of large RNA-protein complexes (RNPs), like the bacterial ribosome, remains a formidable challenge in structural biology. Previous genetic approaches to probe assembly have focused on modulating the expression of either r-proteins or as...

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Bibliographic Details
Main Authors: Kai Sheng, Xiyu Dong, Sriram Aiyer, Joan Lee, Selena Đorđević-Marquardt, Dmitry Lyumkis, James R. Williamson
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61640-1
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