Anti-sense oligonucleotide probing as a structural platform for studying ribonucleoprotein complex assembly
Abstract Investigating the intricate and rapid folding kinetics of large RNA-protein complexes (RNPs), like the bacterial ribosome, remains a formidable challenge in structural biology. Previous genetic approaches to probe assembly have focused on modulating the expression of either r-proteins or as...
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| Main Authors: | Kai Sheng, Xiyu Dong, Sriram Aiyer, Joan Lee, Selena Đorđević-Marquardt, Dmitry Lyumkis, James R. Williamson |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-61640-1 |
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