Effect of combined modality treatment on morphofunctional state of bronchial epithelium in lung cancer patients
Effect of combined modality treatment on morphofunctional state of the bronchial epithelium of 29 patients with stage III lung cancer was studied. Neoadjuvant chemotherapy (paclitaxel/carboplatin) had no negative effect on the state of the bronchial epithelium. Surgery with intraoperative radiation...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2016-02-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/236 |
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| author | A. Yu. Dobrodeev O. V. Pankova A. A. Zavyalov S. A. Tuzikov O, V. Cheremisina |
| author_facet | A. Yu. Dobrodeev O. V. Pankova A. A. Zavyalov S. A. Tuzikov O, V. Cheremisina |
| author_sort | A. Yu. Dobrodeev |
| collection | DOAJ |
| description | Effect of combined modality treatment on morphofunctional state of the bronchial epithelium of 29 patients with stage III lung cancer was studied. Neoadjuvant chemotherapy (paclitaxel/carboplatin) had no negative effect on the state of the bronchial epithelium. Surgery with intraoperative radiation therapy at a single dose of 10 Gy or 15 Gy with cisplatin radiosensitization caused mucosal damage as alteration, dystrophy and desqumation of the covering epithelium. The damaged epithelium was regenerated due to the reserved cells coming from the damaged margins with the formation of an epidermoid regenerative layer and subsequent cell differentiation. In a year after treatment, the bronchial mucosa was covered by the multinuclear cylindrical epithelium and moderate sclerosis occurred in the stroma |
| format | Article |
| id | doaj-art-b36b04ec061f491d8faa2303e19277ee |
| institution | DOAJ |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2016-02-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-b36b04ec061f491d8faa2303e19277ee2025-08-20T03:18:26ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682016-02-01053438236Effect of combined modality treatment on morphofunctional state of bronchial epithelium in lung cancer patientsA. Yu. Dobrodeev0O. V. Pankova1A. A. Zavyalov2S. A. Tuzikov3O, V. Cheremisina4Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, TomskCancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, TomskCancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk, Siberian State Medical University, TomskCancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk, Siberian State Medical University, TomskCancer Research Institute, Siberian Branch of the Russian Academy of Medical SciencesEffect of combined modality treatment on morphofunctional state of the bronchial epithelium of 29 patients with stage III lung cancer was studied. Neoadjuvant chemotherapy (paclitaxel/carboplatin) had no negative effect on the state of the bronchial epithelium. Surgery with intraoperative radiation therapy at a single dose of 10 Gy or 15 Gy with cisplatin radiosensitization caused mucosal damage as alteration, dystrophy and desqumation of the covering epithelium. The damaged epithelium was regenerated due to the reserved cells coming from the damaged margins with the formation of an epidermoid regenerative layer and subsequent cell differentiation. In a year after treatment, the bronchial mucosa was covered by the multinuclear cylindrical epithelium and moderate sclerosis occurred in the stromahttps://www.siboncoj.ru/jour/article/view/236lung cancercombined modality treatmentintraoperative radiation therapybronchial epitheliummorphology |
| spellingShingle | A. Yu. Dobrodeev O. V. Pankova A. A. Zavyalov S. A. Tuzikov O, V. Cheremisina Effect of combined modality treatment on morphofunctional state of bronchial epithelium in lung cancer patients Сибирский онкологический журнал lung cancer combined modality treatment intraoperative radiation therapy bronchial epithelium morphology |
| title | Effect of combined modality treatment on morphofunctional state of bronchial epithelium in lung cancer patients |
| title_full | Effect of combined modality treatment on morphofunctional state of bronchial epithelium in lung cancer patients |
| title_fullStr | Effect of combined modality treatment on morphofunctional state of bronchial epithelium in lung cancer patients |
| title_full_unstemmed | Effect of combined modality treatment on morphofunctional state of bronchial epithelium in lung cancer patients |
| title_short | Effect of combined modality treatment on morphofunctional state of bronchial epithelium in lung cancer patients |
| title_sort | effect of combined modality treatment on morphofunctional state of bronchial epithelium in lung cancer patients |
| topic | lung cancer combined modality treatment intraoperative radiation therapy bronchial epithelium morphology |
| url | https://www.siboncoj.ru/jour/article/view/236 |
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