Heme-Oxygenase 1 Mediated Activation of Cyp3A11 Protects Against Non-Steroidal Pain Analgesics Induced Acute Liver Damage in Sickle Cell Disease Mice

Heme-Oxygenase 1 Mediated Activation of Cyp3A11 Protects Against Non-Steroidal Pain Analgesics Induced Acute Liver Damage in Sickle Cell Disease Mice

Pain constitutes a significant comorbidity associated with sickle cell disease (SCD). Analgesics serve as the primary method for pain management; however, the long-term effects of these drugs on the liver of SCD patients remain not completely understood. Using real-time intravital imaging, we analyz...

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Bibliographic Details
Main Authors: Ravi Vats, Ramakrishna Ungalara, Rikesh K. Dubey, Prithu Sundd, Tirthadipa Pradhan-Sundd
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Cells
Subjects:
sickle cell disease
non-steroidal analgesics
pain management
heme oxygenase 1
Cyp3A11
Kupffer cells
Online Access:https://www.mdpi.com/2073-4409/14/3/194
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