Urolithin A Protects Ovarian Reserve Via Inhibiting PI3K/Akt Signaling and Preventing Chemotherapy-Induced Follicle Apoptosis

Urolithin A Protects Ovarian Reserve Via Inhibiting PI3K/Akt Signaling and Preventing Chemotherapy-Induced Follicle Apoptosis

Urolithin A, which is a natural gut microbial metabolite, exerts multiple beneficial effects upon supplementation, including prolonging lifespan, mitigating diseases, restoring the quality of aged oocytes and alleviating drug toxicity. The study aims to investigate the ovarian protective role of Uro...

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Bibliographic Details
Main Authors: Weiyong Wang, Ren Zhou, Yong Ruan, Shuhao Fan
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Biology
Subjects:
Urolithin A
primordial follicle activation
PI3K/Akt
chemotherapy
Online Access:https://www.mdpi.com/2079-7737/14/7/829
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