Role of glucocorticoid receptor expression in Chronic Chagas Cardiomyopathy: implications for inflammation and cardiac hypertrophy

Role of glucocorticoid receptor expression in Chronic Chagas Cardiomyopathy: implications for inflammation and cardiac hypertrophy

IntroductionChronic Chagasic Cardiomyopathy (CCC) has an infectious and inflammatory nature. Recent data also suggest an association with altered regulation of glucocorticoid (GC)-mediated circuits failing to control systemic inflammation. However, the involvement of glucocorticoid receptors (GR) an...

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Main Authors: Florencia B. González, Antonella Pacini, Araceli Castro, Susana Lioi, Silvina R. Villar, Luciano D’Attilio, Rodolfo D. Leiva, Liliana Favaloro, Oscar A. Bottasso, Carlos A. Vigliano, Ana Rosa Pérez
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Endocrinology
Subjects:
glucocorticoid receptor
11β-hydroxysteroid dehydrogenase type 1
cardiomyocyte
hypertrophy
chronic chagasic cardiomyopathy
ischemic cardiomyopathy
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1486772/full
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https://www.frontiersin.org/articles/10.3389/fendo.2025.1486772/full

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