Inhibition of complement system-related gene ITGB2 attenuates epithelial–mesenchymal transition and inflammation in diabetic nephropathy

Inhibition of complement system-related gene ITGB2 attenuates epithelial–mesenchymal transition and inflammation in diabetic nephropathy

Abstract Purpose Emerging evidences have indicated a role of the complement system in the pathogenesis of diabetic nephropathy (DN). Thus, this study was conducted to explore the complement system-related key biomarkers for patients with DN. Methods DN microarray datasets were downloaded from the GE...

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Bibliographic Details
Main Authors: Jun Peng, Wenqi Zhao, Lu Zhou, Kun Ding
Format: Article
Language:English
Published: BMC 2025-02-01
Series:European Journal of Medical Research
Subjects:
Diabetic nephropathy
Complement system
Immune infiltration
Weighted correlation network analysis
Machine learning
Online Access:https://doi.org/10.1186/s40001-025-02323-x
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