The Emerging Role of Botulinum Neurotoxin in Psoriasis Management: A Review of Mechanisms, Evidence, and Challenges
Psoriasis is a chronic, immune-mediated skin condition characterized by inflammation and accelerated epidermal turnover. Current therapies, including topical and systemic agents, often face limitations such as incomplete efficacy, side effects, and patient compliance issues. Botulinum neurotoxin (Bo...
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| Main Author: | |
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| Format: | Article |
| Language: | English |
| Published: |
International Medical Research and Development Corporation
2025-03-01
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| Series: | International Journal of Biomedicine |
| Subjects: | |
| Online Access: | http://www.ijbm.org/articles/i57/ijbm_15(1)_ra7.pdf |
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| Summary: | Psoriasis is a chronic, immune-mediated skin condition characterized by inflammation and accelerated epidermal turnover. Current therapies, including topical and systemic agents, often face limitations such as incomplete efficacy, side effects, and patient compliance issues. Botulinum neurotoxin (BoNT), traditionally used in cosmetic dermatology and neurology, has emerged as a novel potential treatment due to its ability to modulate neuroinflammatory pathways and immune responses. This review explores the biological basis of BoNT in psoriasis, focusing on its role in inhibiting neuropeptide release, reducing pro-inflammatory cytokines, and interrupting the cycle of neuroinflammation. We examine preclinical studies and clinical trials demonstrating BoNT’s efficacy in reducing psoriasis symptoms, particularly when conventional therapies fall short.
Additionally, the review highlights the safety profile, emphasizing potential side effects such as localized muscle weakness, and discusses challenges, including standardization of dosing and long-term outcomes. Further study of BoNT's therapeutic potential, its role as an additional therapy, and the development of biomarkers for predicting patient responses are of great practical interest. In conclusion, BoNT shows promise as an innovative treatment approach for psoriasis, warranting further investigation to establish its clinical utility. |
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| ISSN: | 2158-0510 2158-0529 |