The P2X7R-antagonist AFC-5128 ameliorates chronic experimental autoimmune encephalomyelitis in a preventive and therapeutic paradigm

The P2X7R-antagonist AFC-5128 ameliorates chronic experimental autoimmune encephalomyelitis in a preventive and therapeutic paradigm

BackgroundMultiple sclerosis (MS) is characterized by chronic inflammation driven by central nervous system (CNS)-resident immune cells such as microglia, especially during the progressive phase of the disease. The P2X7 receptor (P2X7R), a risk protein for MS, is ubiquitously expressed on immune cel...

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Bibliographic Details
Main Authors: Robert Hoffrogge, Anna Karachunskaya, Neele Heitmann, Steffen Haupeltshofer, Xiomara Pedreiturria, Katharina Klöster, Verian Bader, Konstanze F. Winklhofer, Michael Hamacher, Bert Klebl, Ralf Gold, Klaus Dinkel, Ingo Kleiter, Simon Faissner
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
P2X7R
progressive multiple sclerosis
microglia
neuroinflammation
neuroprotection
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1554999/full
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