ONECUT2 reprograms neuroendocrine fate and is an actionable therapeutic target in small cell lung cancer

ONECUT2 reprograms neuroendocrine fate and is an actionable therapeutic target in small cell lung cancer

Abstract Small cell lung cancer (SCLC) is a highly aggressive malignancy with extremely poor prognosis. SCLC cells exhibit high plasticity and can progress from neuroendocrine (NE) to non-NE phenotypes. This dynamic evolution promotes treatment resistance and relapses, representing a challenge for t...

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Main Authors: Mirian Gutiérrez, Irene Zamora, Raquel Iriarte, María José Pajares, Qian Yang, Chen Qian, Nerea Otegui, Joaquín Fernández-Irigoyen, Enrique Santamaría, Nicolas Alcala, Alexandra Sexton-Oates, Lynnette Fernández-Cuesta, Miguel Barajas, Alfonso Calvo, Luis M. Montuenga, Beatrice Knudsen, Sungyong You, Michael R. Freeman, Ignacio Encío, Mirja Rotinen
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Molecular Medicine
Subjects:
ONECUT2
SCLC
Tumor heterogeneity
Phenotypic plasticity
Therapeutic target
Online Access:https://doi.org/10.1186/s10020-025-01267-6
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