The pathogenesis and targeted therapies of intervertebral disc degeneration induced by cartilage endplate inflammation

The pathogenesis and targeted therapies of intervertebral disc degeneration induced by cartilage endplate inflammation

Intervertebral disc degeneration (IVDD) is the leading cause of low back pain, where degeneration and death of nucleus pulposus cells within the intervertebral disc (IVD) can be obviously revealed. This degeneration can result in an imbalance in the extracellular matrix due to the loss of proteoglyc...

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Bibliographic Details
Main Authors:	Hantao Yang, Xuandu Chen, Jun Chen, Yansong Dong, Yafang Huang, Lei Qin, Jie Tan, Weihong Yi
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-12-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	intervertebral disc degeneration cartilage endplate inflammation exosomes calcification ferroptosis
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2024.1492870/full
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