Amugulang virus, a novel hantavirus harboured by small rodents in Hulunbuir, China
The Hulunbuir region, known for its diverse terrain and rich wildlife, is a hotspot for various natural epidemic diseases. Between 2021 and 2023, we collected 885 wild rodent samples from this area, representing three families, seven genera, and eleven species. Metagenomic analysis identified three...
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Taylor & Francis Group
2024-12-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2024.2396893 |
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| author | Xiaohu Han Lianhong Zhang Mingxuan Zhang Qing Xin Yongxiang Zhao Ya Wen Hua Deng Jinguo Zhu Qin Dai Mei Han Tianyu Yang Saiji Lahu Feng Jiang Zeliang Chen |
| author_facet | Xiaohu Han Lianhong Zhang Mingxuan Zhang Qing Xin Yongxiang Zhao Ya Wen Hua Deng Jinguo Zhu Qin Dai Mei Han Tianyu Yang Saiji Lahu Feng Jiang Zeliang Chen |
| author_sort | Xiaohu Han |
| collection | DOAJ |
| description | The Hulunbuir region, known for its diverse terrain and rich wildlife, is a hotspot for various natural epidemic diseases. Between 2021 and 2023, we collected 885 wild rodent samples from this area, representing three families, seven genera, and eleven species. Metagenomic analysis identified three complete nucleic acid sequences from the S, M, and L segments of the Hantaviridae family, which were closely related to the Khabarovsk virus. The nucleotide coding sequences for S, M, and L (1392 nt, 3465 nt, and 6491 nt, respectively) exhibited similarities of 82.34%, 81.68%, and 81.94% to known sequences, respectively, while protein-level analysis indicated higher similarities of 94.92%, 94.41%, and 95.87%, respectively. Phylogenetic analysis placed these sequences within the same clade as the Khabarovsk, Puumala, Muju, Hokkaido, Topografov, and Tatenalense viruses, all of which are known to cause febrile diseases in humans. Immunofluorescence detection of nucleic acid-positive rodent kidney samples using sera from patients with hemorrhagic fever and renal syndrome confirmed the presence of viral particles. Based on these findings, we propose that this virus represents a new member of the Hantaviridae family, tentatively named the Amugulang virus, after its primary distribution area. |
| format | Article |
| id | doaj-art-b347e53f726a424bbec563266e193e2b |
| institution | OA Journals |
| issn | 2222-1751 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-b347e53f726a424bbec563266e193e2b2025-08-20T02:37:32ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512024-12-0113110.1080/22221751.2024.2396893Amugulang virus, a novel hantavirus harboured by small rodents in Hulunbuir, ChinaXiaohu Han0Lianhong Zhang1Mingxuan Zhang2Qing Xin3Yongxiang Zhao4Ya Wen5Hua Deng6Jinguo Zhu7Qin Dai8Mei Han9Tianyu Yang10Saiji Lahu11Feng Jiang12Zeliang Chen13Key Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, People’s Republic of ChinaKey Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, People’s Republic of ChinaManzhouli International Travel Health Care Center, Manzhouli, Inner Mongolia, People’s Republic of ChinaKey Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, People’s Republic of ChinaThe Sixth People's Hospital of Dandong City, Dandong, Liaoning, People’s Republic of ChinaThe Sixth People's Hospital of Dandong City, Dandong, Liaoning, People’s Republic of ChinaManzhouli International Travel Health Care Center, Manzhouli, Inner Mongolia, People’s Republic of ChinaManzhouli International Travel Health Care Center, Manzhouli, Inner Mongolia, People’s Republic of ChinaManzhouli International Travel Health Care Center, Manzhouli, Inner Mongolia, People’s Republic of ChinaKey Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, People’s Republic of ChinaKey Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, People’s Republic of ChinaTongliao Centers for Disease Control and Prevention, Tongliao, Inner Mongolia, People’s Republic of ChinaKey Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, People’s Republic of ChinaKey Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, People’s Republic of ChinaThe Hulunbuir region, known for its diverse terrain and rich wildlife, is a hotspot for various natural epidemic diseases. Between 2021 and 2023, we collected 885 wild rodent samples from this area, representing three families, seven genera, and eleven species. Metagenomic analysis identified three complete nucleic acid sequences from the S, M, and L segments of the Hantaviridae family, which were closely related to the Khabarovsk virus. The nucleotide coding sequences for S, M, and L (1392 nt, 3465 nt, and 6491 nt, respectively) exhibited similarities of 82.34%, 81.68%, and 81.94% to known sequences, respectively, while protein-level analysis indicated higher similarities of 94.92%, 94.41%, and 95.87%, respectively. Phylogenetic analysis placed these sequences within the same clade as the Khabarovsk, Puumala, Muju, Hokkaido, Topografov, and Tatenalense viruses, all of which are known to cause febrile diseases in humans. Immunofluorescence detection of nucleic acid-positive rodent kidney samples using sera from patients with hemorrhagic fever and renal syndrome confirmed the presence of viral particles. Based on these findings, we propose that this virus represents a new member of the Hantaviridae family, tentatively named the Amugulang virus, after its primary distribution area.https://www.tandfonline.com/doi/10.1080/22221751.2024.2396893HantavirusAmugulang virusHulunbuirAmugulang Portemerging infectious diseases |
| spellingShingle | Xiaohu Han Lianhong Zhang Mingxuan Zhang Qing Xin Yongxiang Zhao Ya Wen Hua Deng Jinguo Zhu Qin Dai Mei Han Tianyu Yang Saiji Lahu Feng Jiang Zeliang Chen Amugulang virus, a novel hantavirus harboured by small rodents in Hulunbuir, China Emerging Microbes and Infections Hantavirus Amugulang virus Hulunbuir Amugulang Port emerging infectious diseases |
| title | Amugulang virus, a novel hantavirus harboured by small rodents in Hulunbuir, China |
| title_full | Amugulang virus, a novel hantavirus harboured by small rodents in Hulunbuir, China |
| title_fullStr | Amugulang virus, a novel hantavirus harboured by small rodents in Hulunbuir, China |
| title_full_unstemmed | Amugulang virus, a novel hantavirus harboured by small rodents in Hulunbuir, China |
| title_short | Amugulang virus, a novel hantavirus harboured by small rodents in Hulunbuir, China |
| title_sort | amugulang virus a novel hantavirus harboured by small rodents in hulunbuir china |
| topic | Hantavirus Amugulang virus Hulunbuir Amugulang Port emerging infectious diseases |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2024.2396893 |
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