USP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation

USP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation

Abstract The N6-methyladenosine binding protein YTHDF1, often upregulated in cancer, promotes tumor growth and hinders immune checkpoint blockade treatment. A comprehensive understanding of the molecular mechanisms governing YTHDF1 protein stability is pivotal for enhancing clinical response rates a...

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Main Authors: Na Shao, Lei Xi, Yangfan Lv, Muhammad Idris, Lin Zhang, Ya Cao, Jingyi Xiang, Xi Xu, Belinda X. Ong, Qiongyi Zhang, Xu Peng, Xiaoyan Yue, Feng Xu, Chungang Liu
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56564-9
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