A Mechanistic Insight into the Anti-Staphylococcal Mode of Action of (+)-Usnic Acid and Its Synergy with Norfloxacin Against Methicillin-Resistant <i>Staphylococcus aureus</i>

A Mechanistic Insight into the Anti-Staphylococcal Mode of Action of (+)-Usnic Acid and Its Synergy with Norfloxacin Against Methicillin-Resistant <i>Staphylococcus aureus</i>

In this study, a global response analysis was performed to explore the mechanism of action of Usnic acid and its synergy with Norfloxacin, a well-known quinolone antibiotic to which MRSA clinical isolates showed resistance (MIC, 500 µg/mL). A microdilution assay, a growth kinetics analysis, a micros...

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Bibliographic Details
Main Authors: Bhavana Gangwar, Santosh Kumar, Parmanand Kumar, Anirban Pal, Mahendra P. Darokar
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Biomolecules
Subjects:
antimicrobial resistance
natural therapeutics
gel-free proteomics
gene expression
methicillin-resistant <i>Staphylococcus aureus</i> (MRSA)
synergy
Online Access:https://www.mdpi.com/2218-273X/15/6/750
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