Plasmid-mediated tigecycline-resistant gene tet(X4) in Escherichia coli from food-producing animals, China, 2008–2018
The recent emergence of plasmid-mediated tigecycline resistance genes, tet(X3) and tet(X4), in animals and humans in China would pose a foreseeable threat to public health. To illustrate this paradigm shift in tigecycline resistance, here, covering the period 2008-2018, we retrospectively analysed a...
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| Format: | Article |
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Taylor & Francis Group
2019-01-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2019.1678367 |
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| author | Chengtao Sun Mingquan Cui Shan Zhang Hejia Wang Li Song Chunping Zhang Qi Zhao Dejun Liu Yang Wang Jianzhong Shen Shixin Xu Congming Wu |
| author_facet | Chengtao Sun Mingquan Cui Shan Zhang Hejia Wang Li Song Chunping Zhang Qi Zhao Dejun Liu Yang Wang Jianzhong Shen Shixin Xu Congming Wu |
| author_sort | Chengtao Sun |
| collection | DOAJ |
| description | The recent emergence of plasmid-mediated tigecycline resistance genes, tet(X3) and tet(X4), in animals and humans in China would pose a foreseeable threat to public health. To illustrate this paradigm shift in tigecycline resistance, here, covering the period 2008-2018, we retrospectively analysed a national strain collection of Escherichia coli (n = 2254), obtained from chickens and pigs, in six representative provinces of China. The gene tet(X4) was identified in five pig isolates collected in 2016 and 2018 from the provinces of Sichuan (3/15, 2018), Henan (1/25, 2018) and Guangdong (1/28, 2016), but not in the isolates prior to 2016. None of the isolates was detected harbouring tet(X3). All tet(X4)-positive E. coli exhibited high levels of tigecycline resistance (MICs, 16-64 mg/L), and two were confirmed as colistin resistant, harbouring chromosome-borne mcr-1 gene. The gene tet(X4) was detected on a plasmid in all five isolates, whereas a co-location of tet(X4) on the chromosome of one isolate was observed. Diverse host strains and novel plasmids related to the tet(X4) gene were observed. Our timely findings of the recent emergence of tet(X4) gene in food animal support the rapid surveillance and eradication of this gene before it is established. |
| format | Article |
| id | doaj-art-b32ea24344384573b06695c120163e13 |
| institution | DOAJ |
| issn | 2222-1751 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-b32ea24344384573b06695c120163e132025-08-20T03:17:32ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512019-01-01811524152710.1080/22221751.2019.1678367Plasmid-mediated tigecycline-resistant gene tet(X4) in Escherichia coli from food-producing animals, China, 2008–2018Chengtao Sun0Mingquan Cui1Shan Zhang2Hejia Wang3Li Song4Chunping Zhang5Qi Zhao6Dejun Liu7Yang Wang8Jianzhong Shen9Shixin Xu10Congming Wu11Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, People’s Republic of ChinaChina Institute of Veterinary Drug Control, Beijing, People’s Republic of ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, People’s Republic of ChinaChina Institute of Veterinary Drug Control, Beijing, People’s Republic of ChinaChina Institute of Veterinary Drug Control, Beijing, People’s Republic of ChinaChina Institute of Veterinary Drug Control, Beijing, People’s Republic of ChinaChina Institute of Veterinary Drug Control, Beijing, People’s Republic of ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, People’s Republic of ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, People’s Republic of ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, People’s Republic of ChinaChina Institute of Veterinary Drug Control, Beijing, People’s Republic of ChinaBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, People’s Republic of ChinaThe recent emergence of plasmid-mediated tigecycline resistance genes, tet(X3) and tet(X4), in animals and humans in China would pose a foreseeable threat to public health. To illustrate this paradigm shift in tigecycline resistance, here, covering the period 2008-2018, we retrospectively analysed a national strain collection of Escherichia coli (n = 2254), obtained from chickens and pigs, in six representative provinces of China. The gene tet(X4) was identified in five pig isolates collected in 2016 and 2018 from the provinces of Sichuan (3/15, 2018), Henan (1/25, 2018) and Guangdong (1/28, 2016), but not in the isolates prior to 2016. None of the isolates was detected harbouring tet(X3). All tet(X4)-positive E. coli exhibited high levels of tigecycline resistance (MICs, 16-64 mg/L), and two were confirmed as colistin resistant, harbouring chromosome-borne mcr-1 gene. The gene tet(X4) was detected on a plasmid in all five isolates, whereas a co-location of tet(X4) on the chromosome of one isolate was observed. Diverse host strains and novel plasmids related to the tet(X4) gene were observed. Our timely findings of the recent emergence of tet(X4) gene in food animal support the rapid surveillance and eradication of this gene before it is established.https://www.tandfonline.com/doi/10.1080/22221751.2019.1678367Mobile tigecycline resistanceEscherichia colifood-producing animalsretrospective analysisChina |
| spellingShingle | Chengtao Sun Mingquan Cui Shan Zhang Hejia Wang Li Song Chunping Zhang Qi Zhao Dejun Liu Yang Wang Jianzhong Shen Shixin Xu Congming Wu Plasmid-mediated tigecycline-resistant gene tet(X4) in Escherichia coli from food-producing animals, China, 2008–2018 Emerging Microbes and Infections Mobile tigecycline resistance Escherichia coli food-producing animals retrospective analysis China |
| title | Plasmid-mediated tigecycline-resistant gene tet(X4) in Escherichia coli from food-producing animals, China, 2008–2018 |
| title_full | Plasmid-mediated tigecycline-resistant gene tet(X4) in Escherichia coli from food-producing animals, China, 2008–2018 |
| title_fullStr | Plasmid-mediated tigecycline-resistant gene tet(X4) in Escherichia coli from food-producing animals, China, 2008–2018 |
| title_full_unstemmed | Plasmid-mediated tigecycline-resistant gene tet(X4) in Escherichia coli from food-producing animals, China, 2008–2018 |
| title_short | Plasmid-mediated tigecycline-resistant gene tet(X4) in Escherichia coli from food-producing animals, China, 2008–2018 |
| title_sort | plasmid mediated tigecycline resistant gene tet x4 in escherichia coli from food producing animals china 2008 2018 |
| topic | Mobile tigecycline resistance Escherichia coli food-producing animals retrospective analysis China |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2019.1678367 |
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