Topical Rifamycin Prophylaxis in Gynecological and Obstetric Surgery
OBJECTIVE: Antibiotic prophylaxis is one of the most important steps to reduce surgical site infections. First-generation cephalosporin (cefazolin) is used prophylactically in the majority of operations. Rifamycin is a broad-spectrum semisynthetic antibiotic that is bactericidal against gram (+) an...
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| Format: | Article |
| Language: | English |
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Medical Network
2022-03-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
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| Online Access: | https://gorm.com.tr/index.php/GORM/article/view/1193 |
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| author | Nahit Ata Mehmet Kulhan Nur Gozde Kulhan Can Turkler Ahmet Bilgi Cetin Celik |
| author_facet | Nahit Ata Mehmet Kulhan Nur Gozde Kulhan Can Turkler Ahmet Bilgi Cetin Celik |
| author_sort | Nahit Ata |
| collection | DOAJ |
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OBJECTIVE: Antibiotic prophylaxis is one of the most important steps to reduce surgical site infections. First-generation cephalosporin (cefazolin) is used prophylactically in the majority of operations. Rifamycin is a broad-spectrum semisynthetic antibiotic that is bactericidal against gram (+) and gram (˗) microorganisms. To the best of our knowledge, there are no studies on the use of rifamycin in antibiotic prophylaxis. In this study, we aimed to analyze whether there is a difference between the use of only cefazolin and only rifamycin in terms of surgical site infections.
STUDY DESIGN: One hundred patients were included in this case-control study during the last quarter period of 2017. These patients (n=100) were divided into two groups according to their antibiotic use; 50 patients who received only 1 g cefazolin constituted Group 1, 50 patients who received only 250 mg topical rifamycin over the incision line based on surgeon’s preference constituted Group 2.
RESULTS: The use of prophylactic topical rifamycin reduced the incidence of wound infection. compared with cefazolin. Surgical site infection was detected in 5 (10%) of the patients who received cefazolin, whereas surgical site infection was not observed in patients who received rifamycin (p=0.022).
CONCLUSIONS: The use of topical rifamycin is effective but does not imply that systemic antibiotics should replace prophylaxis. The use of rifamycin would aid in systemic antibiotic prophylaxis.
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| format | Article |
| id | doaj-art-b324c8dc29674b809eaa3133c3c438e9 |
| institution | Kabale University |
| issn | 1300-4751 2602-4918 |
| language | English |
| publishDate | 2022-03-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj-art-b324c8dc29674b809eaa3133c3c438e92025-02-11T21:14:41ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512602-49182022-03-0128110.21613/GORM.2021.1193Topical Rifamycin Prophylaxis in Gynecological and Obstetric SurgeryNahit Ata0Mehmet Kulhan1Nur Gozde Kulhan2Can Turkler3Ahmet Bilgi4Cetin Celik5Erzincan Binali Yildirim UniversitySelcuk UniverstiyKonya City HospitalErzincan Binali Yildirim UniversitySelcuk UniversitySelcuk University OBJECTIVE: Antibiotic prophylaxis is one of the most important steps to reduce surgical site infections. First-generation cephalosporin (cefazolin) is used prophylactically in the majority of operations. Rifamycin is a broad-spectrum semisynthetic antibiotic that is bactericidal against gram (+) and gram (˗) microorganisms. To the best of our knowledge, there are no studies on the use of rifamycin in antibiotic prophylaxis. In this study, we aimed to analyze whether there is a difference between the use of only cefazolin and only rifamycin in terms of surgical site infections. STUDY DESIGN: One hundred patients were included in this case-control study during the last quarter period of 2017. These patients (n=100) were divided into two groups according to their antibiotic use; 50 patients who received only 1 g cefazolin constituted Group 1, 50 patients who received only 250 mg topical rifamycin over the incision line based on surgeon’s preference constituted Group 2. RESULTS: The use of prophylactic topical rifamycin reduced the incidence of wound infection. compared with cefazolin. Surgical site infection was detected in 5 (10%) of the patients who received cefazolin, whereas surgical site infection was not observed in patients who received rifamycin (p=0.022). CONCLUSIONS: The use of topical rifamycin is effective but does not imply that systemic antibiotics should replace prophylaxis. The use of rifamycin would aid in systemic antibiotic prophylaxis. https://gorm.com.tr/index.php/GORM/article/view/1193Antibiotic prophylaxisCefazolinSurgical site infectionTopical rifamycin |
| spellingShingle | Nahit Ata Mehmet Kulhan Nur Gozde Kulhan Can Turkler Ahmet Bilgi Cetin Celik Topical Rifamycin Prophylaxis in Gynecological and Obstetric Surgery Gynecology Obstetrics & Reproductive Medicine Antibiotic prophylaxis Cefazolin Surgical site infection Topical rifamycin |
| title | Topical Rifamycin Prophylaxis in Gynecological and Obstetric Surgery |
| title_full | Topical Rifamycin Prophylaxis in Gynecological and Obstetric Surgery |
| title_fullStr | Topical Rifamycin Prophylaxis in Gynecological and Obstetric Surgery |
| title_full_unstemmed | Topical Rifamycin Prophylaxis in Gynecological and Obstetric Surgery |
| title_short | Topical Rifamycin Prophylaxis in Gynecological and Obstetric Surgery |
| title_sort | topical rifamycin prophylaxis in gynecological and obstetric surgery |
| topic | Antibiotic prophylaxis Cefazolin Surgical site infection Topical rifamycin |
| url | https://gorm.com.tr/index.php/GORM/article/view/1193 |
| work_keys_str_mv | AT nahitata topicalrifamycinprophylaxisingynecologicalandobstetricsurgery AT mehmetkulhan topicalrifamycinprophylaxisingynecologicalandobstetricsurgery AT nurgozdekulhan topicalrifamycinprophylaxisingynecologicalandobstetricsurgery AT canturkler topicalrifamycinprophylaxisingynecologicalandobstetricsurgery AT ahmetbilgi topicalrifamycinprophylaxisingynecologicalandobstetricsurgery AT cetincelik topicalrifamycinprophylaxisingynecologicalandobstetricsurgery |