Successful use of splenectomy in a patient with hepatitis C virus-related thrombocytopenia
This case report describes a 44-year-old female with hepatitis C virus-related thrombocytopenia. The laboratory tests showed a platelet count of 3×109/l, positive HCV serology and high serum concentration of HCV-RNA of 6.74×106 copy/ml. She was refractory to standard therapies including corticostero...
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| Format: | Article |
| Language: | English |
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The Journal of Infection in Developing Countries
2015-07-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/5084 |
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| author | Xilian Huang Yaping Xie Daquan Gao Pengfei Shi Shenxian Qian |
| author_facet | Xilian Huang Yaping Xie Daquan Gao Pengfei Shi Shenxian Qian |
| author_sort | Xilian Huang |
| collection | DOAJ |
| description | This case report describes a 44-year-old female with hepatitis C virus-related thrombocytopenia. The laboratory tests showed a platelet count of 3×109/l, positive HCV serology and high serum concentration of HCV-RNA of 6.74×106 copy/ml. She was refractory to standard therapies including corticosteroids, intravenous immunoglobulin (IVIG), thrombopoietin (TPO) and even interferon (IFN) regimens, due to the persistence of a low platelet count. At first, splenectomy was thought to be impossible, but then splenectomy was successfully performed and patient showed good tolerance and a constant normal platelet count after surgery. In conclusion, splenectomy is feasible in selected patients and may allow us to acquire a reasonable platelet count and completion of an anti-HCV protocol. Low platelet count itself should not be the contraindication of operation specifically for these patients. Further studies in larger numbers of patients and over a longer period of time are warranted.
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| format | Article |
| id | doaj-art-b324029cc448452e89244fca68c88d42 |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2015-07-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-b324029cc448452e89244fca68c88d422025-08-20T02:16:14ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802015-07-0190710.3855/jidc.5084Successful use of splenectomy in a patient with hepatitis C virus-related thrombocytopeniaXilian Huang0Yaping Xie1Daquan Gao2Pengfei Shi3Shenxian Qian4Hangzhou First People’s Hospital, Hangzhou, ChinaHangzhou First People’s Hospital, Hangzhou, ChinaHangzhou First People’s Hospital, Hangzhou, ChinaHangzhou First People’s Hospital, Hangzhou, ChinaHangzhou First People’s Hospital, Hangzhou, ChinaThis case report describes a 44-year-old female with hepatitis C virus-related thrombocytopenia. The laboratory tests showed a platelet count of 3×109/l, positive HCV serology and high serum concentration of HCV-RNA of 6.74×106 copy/ml. She was refractory to standard therapies including corticosteroids, intravenous immunoglobulin (IVIG), thrombopoietin (TPO) and even interferon (IFN) regimens, due to the persistence of a low platelet count. At first, splenectomy was thought to be impossible, but then splenectomy was successfully performed and patient showed good tolerance and a constant normal platelet count after surgery. In conclusion, splenectomy is feasible in selected patients and may allow us to acquire a reasonable platelet count and completion of an anti-HCV protocol. Low platelet count itself should not be the contraindication of operation specifically for these patients. Further studies in larger numbers of patients and over a longer period of time are warranted. https://jidc.org/index.php/journal/article/view/5084hepatitis Cthrombocytopenicsplenectomy |
| spellingShingle | Xilian Huang Yaping Xie Daquan Gao Pengfei Shi Shenxian Qian Successful use of splenectomy in a patient with hepatitis C virus-related thrombocytopenia Journal of Infection in Developing Countries hepatitis C thrombocytopenic splenectomy |
| title | Successful use of splenectomy in a patient with hepatitis C virus-related thrombocytopenia |
| title_full | Successful use of splenectomy in a patient with hepatitis C virus-related thrombocytopenia |
| title_fullStr | Successful use of splenectomy in a patient with hepatitis C virus-related thrombocytopenia |
| title_full_unstemmed | Successful use of splenectomy in a patient with hepatitis C virus-related thrombocytopenia |
| title_short | Successful use of splenectomy in a patient with hepatitis C virus-related thrombocytopenia |
| title_sort | successful use of splenectomy in a patient with hepatitis c virus related thrombocytopenia |
| topic | hepatitis C thrombocytopenic splenectomy |
| url | https://jidc.org/index.php/journal/article/view/5084 |
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