Anti-endothelial cell antibodies in pathogenesis of vasculitis
Vasculitis is a group of syndromes characterized by inflammation, presence of autoantibodies and endothelial cells (ECs) damage, which lead to stenosis or occlusion of the vascular lumen. Anti-endothelial cell antibodies (AECAs) are a heterogeneous group of autoantibodies in vasculitis. AECAs bind t...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-04-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1567293/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849310744585175040 |
|---|---|
| author | Tian Zhang Tian Zhang Tian Zhang Liqun Li Shengshi Huang Shengshi Huang Shengshi Huang Maria N. Starodubtseva Maria N. Starodubtseva Ju Liu Ju Liu Ju Liu |
| author_facet | Tian Zhang Tian Zhang Tian Zhang Liqun Li Shengshi Huang Shengshi Huang Shengshi Huang Maria N. Starodubtseva Maria N. Starodubtseva Ju Liu Ju Liu Ju Liu |
| author_sort | Tian Zhang |
| collection | DOAJ |
| description | Vasculitis is a group of syndromes characterized by inflammation, presence of autoantibodies and endothelial cells (ECs) damage, which lead to stenosis or occlusion of the vascular lumen. Anti-endothelial cell antibodies (AECAs) are a heterogeneous group of autoantibodies in vasculitis. AECAs bind to antigens and membrane-bound proteins of ECs, inducing inflammation, coagulation, and apoptosis. In this review, we discuss the pathological role of AECAs in different types of vasculitis. In addition, AECAs potentially induce alterations of ECs mechanical properties, and subsequently promotes angiogenic phenotypes in the occurrence of vasculitis. |
| format | Article |
| id | doaj-art-b31d3a0e33f243ef9d2ad428186a6727 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-b31d3a0e33f243ef9d2ad428186a67272025-08-20T03:53:38ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-04-011610.3389/fimmu.2025.15672931567293Anti-endothelial cell antibodies in pathogenesis of vasculitisTian Zhang0Tian Zhang1Tian Zhang2Liqun Li3Shengshi Huang4Shengshi Huang5Shengshi Huang6Maria N. Starodubtseva7Maria N. Starodubtseva8Ju Liu9Ju Liu10Ju Liu11Laboratory of Translational Medicine in Microvascular Regulation, Medical Research Center, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, ChinaShandong Provincial Key Medical and Health Laboratory of Translational Medicine in Microvascular Aging, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, ChinaLaboraotry for Future Industry in Gene Editing in Vascular Endothelial Cells of Universities of Shandong Province, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, ChinaDepartment of Clinical Laboratory, Qingdao Municipal Hospital, University of Health and Rehabilitation Sciences, Qingdao, Shandong, ChinaLaboratory of Translational Medicine in Microvascular Regulation, Medical Research Center, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, ChinaShandong Provincial Key Medical and Health Laboratory of Translational Medicine in Microvascular Aging, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, ChinaLaboraotry for Future Industry in Gene Editing in Vascular Endothelial Cells of Universities of Shandong Province, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, ChinaGomel State Medical University, Gomel, BelarusInstitute of Radiobiology of NAS of Belarus, Gomel, BelarusLaboratory of Translational Medicine in Microvascular Regulation, Medical Research Center, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, ChinaShandong Provincial Key Medical and Health Laboratory of Translational Medicine in Microvascular Aging, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, ChinaLaboraotry for Future Industry in Gene Editing in Vascular Endothelial Cells of Universities of Shandong Province, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, ChinaVasculitis is a group of syndromes characterized by inflammation, presence of autoantibodies and endothelial cells (ECs) damage, which lead to stenosis or occlusion of the vascular lumen. Anti-endothelial cell antibodies (AECAs) are a heterogeneous group of autoantibodies in vasculitis. AECAs bind to antigens and membrane-bound proteins of ECs, inducing inflammation, coagulation, and apoptosis. In this review, we discuss the pathological role of AECAs in different types of vasculitis. In addition, AECAs potentially induce alterations of ECs mechanical properties, and subsequently promotes angiogenic phenotypes in the occurrence of vasculitis.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1567293/fullvasculitisendothelial cellsanti-endothelial cell antibodies (AECAs)angiogenesismechanical propertiesstiffness |
| spellingShingle | Tian Zhang Tian Zhang Tian Zhang Liqun Li Shengshi Huang Shengshi Huang Shengshi Huang Maria N. Starodubtseva Maria N. Starodubtseva Ju Liu Ju Liu Ju Liu Anti-endothelial cell antibodies in pathogenesis of vasculitis Frontiers in Immunology vasculitis endothelial cells anti-endothelial cell antibodies (AECAs) angiogenesis mechanical properties stiffness |
| title | Anti-endothelial cell antibodies in pathogenesis of vasculitis |
| title_full | Anti-endothelial cell antibodies in pathogenesis of vasculitis |
| title_fullStr | Anti-endothelial cell antibodies in pathogenesis of vasculitis |
| title_full_unstemmed | Anti-endothelial cell antibodies in pathogenesis of vasculitis |
| title_short | Anti-endothelial cell antibodies in pathogenesis of vasculitis |
| title_sort | anti endothelial cell antibodies in pathogenesis of vasculitis |
| topic | vasculitis endothelial cells anti-endothelial cell antibodies (AECAs) angiogenesis mechanical properties stiffness |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1567293/full |
| work_keys_str_mv | AT tianzhang antiendothelialcellantibodiesinpathogenesisofvasculitis AT tianzhang antiendothelialcellantibodiesinpathogenesisofvasculitis AT tianzhang antiendothelialcellantibodiesinpathogenesisofvasculitis AT liqunli antiendothelialcellantibodiesinpathogenesisofvasculitis AT shengshihuang antiendothelialcellantibodiesinpathogenesisofvasculitis AT shengshihuang antiendothelialcellantibodiesinpathogenesisofvasculitis AT shengshihuang antiendothelialcellantibodiesinpathogenesisofvasculitis AT marianstarodubtseva antiendothelialcellantibodiesinpathogenesisofvasculitis AT marianstarodubtseva antiendothelialcellantibodiesinpathogenesisofvasculitis AT juliu antiendothelialcellantibodiesinpathogenesisofvasculitis AT juliu antiendothelialcellantibodiesinpathogenesisofvasculitis AT juliu antiendothelialcellantibodiesinpathogenesisofvasculitis |