Heat-induced denaturation of cataract-related human γD-crystallin

Heat-induced denaturation of cataract-related human γD-crystallin

Objective To reveal the thermally induced denaturation of wild-type human γD-crystallin(HGD) and congenital cataract-related mutant (HGD P23T), and compare the differences in the structural changes between wild-type and mutants during a heating process. Methods HGD and HGD P23T were expressed and...

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Bibliographic Details
Main Author:	ZHOU Xin, LI Zhenyan, LI Shuyuan, ZHANG Wenbo, WANG Chenxuan
Format:	Article
Language:	zho
Published:	Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. 2025-01-01
Series:	Jichu yixue yu linchuang
Subjects:	crystallin\|thermal stability\|aggregation\|intrinsic fluorescence\|static light scattering
Online Access:	https://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2025-45-1-1.pdf
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