A novel oncolytic Vaccinia virus armed with IL-12 augments antitumor immune responses leading to durable regression in murine models of lung cancer

A novel oncolytic Vaccinia virus armed with IL-12 augments antitumor immune responses leading to durable regression in murine models of lung cancer

Oncolytic vaccinia viruses (VVs) are potent stimulators of the immune system and induce immune-mediated tumor clearance and long-term surveillance against tumor recurrence. As such they are ideal treatment modalities for solid tumors including lung cancer. Here, we investigated the use of VVL-m12, a...

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Bibliographic Details
Main Authors: Lijuan Chen, Pengju Wang, Carmela Di Gioia, Ming Yuan, Zhe Zhang, Jinxin Miao, Wenli Yan, Guanghao Zhao, Yangyang Jia, Na Wang, Zhongxian Zhang, Haoran Guo, Giulia Marelli, Louisa Chard Dunmall, Nicholas R. Lemoine, Yaohe Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
Vaccinia virus
lung cancer
interleukin-12
soluble PD-1
immune checkpoint inhibitor
oncolytic therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1492464/full
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