Establishment and Verification of Synchronous Metastatic Nomogram for Gastrointestinal Stromal Tumors (GISTs): A Population-Based Analysis
Aim. Assess the risk of synchronous metastasis and establish a nomogram in patients with GISTs. Methods. Surveillance, Epidemiology and End Results database (2004-2014) was accessed. With the logistic regression model as the basis, a nomogram was constructed. Results. 7,256 target patients were cont...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2020/8493707 |
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| author | Yuqiang Li Guangfeng Zhang Xiangping Song Lilan Zhao Cenap Güngör Dan Wang Wenxue Liu Yan Huang Fengbo Tan |
| author_facet | Yuqiang Li Guangfeng Zhang Xiangping Song Lilan Zhao Cenap Güngör Dan Wang Wenxue Liu Yan Huang Fengbo Tan |
| author_sort | Yuqiang Li |
| collection | DOAJ |
| description | Aim. Assess the risk of synchronous metastasis and establish a nomogram in patients with GISTs. Methods. Surveillance, Epidemiology and End Results database (2004-2014) was accessed. With the logistic regression model as the basis, a nomogram was constructed. Results. 7,256 target patients were contained in our study. The nomogram discrimination for mGIST prediction revealed that tumor size contributed most to synchronous metastasis, followed by lymph nodes, extension, pathologic grade, tumor location, and mitotic count. C-index values of predictions were 0.821 (95% CI, 0.805-0.836) and 0.815 (95% CI, 0.800-0.831), and Brier score were 0.109 and 0.112 in training and validation group, respectively. The value of area under the ROCs were 0.813 (p<0.001) in the primary cohort and 0.819 (p<0.001) in the validation cohort. Through the calibration curves (as seen in the figures), nomogram prediction proved to have excellent agreement with actual metastatic diseases. Conclusion. A new nomogram was created that can evaluate synchronous metastatic diseases in patients with GISTs. |
| format | Article |
| id | doaj-art-b30f2e2b758142ecbfe600404d0304eb |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-b30f2e2b758142ecbfe600404d0304eb2025-08-20T03:39:18ZengWileyGastroenterology Research and Practice1687-61211687-630X2020-01-01202010.1155/2020/84937078493707Establishment and Verification of Synchronous Metastatic Nomogram for Gastrointestinal Stromal Tumors (GISTs): A Population-Based AnalysisYuqiang Li0Guangfeng Zhang1Xiangping Song2Lilan Zhao3Cenap Güngör4Dan Wang5Wenxue Liu6Yan Huang7Fengbo Tan8Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University, Changsha, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macao, ChinaDepartment of Gastrointestinal Surgery, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Thoracic Surgery, Fujian Provincial Hospital, Fuzhou, ChinaDepartment of General Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyDepartment of Gastrointestinal Surgery, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Rheumatology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaKey Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, ChinaDepartment of Gastrointestinal Surgery, Xiangya Hospital, Central South University, Changsha, ChinaAim. Assess the risk of synchronous metastasis and establish a nomogram in patients with GISTs. Methods. Surveillance, Epidemiology and End Results database (2004-2014) was accessed. With the logistic regression model as the basis, a nomogram was constructed. Results. 7,256 target patients were contained in our study. The nomogram discrimination for mGIST prediction revealed that tumor size contributed most to synchronous metastasis, followed by lymph nodes, extension, pathologic grade, tumor location, and mitotic count. C-index values of predictions were 0.821 (95% CI, 0.805-0.836) and 0.815 (95% CI, 0.800-0.831), and Brier score were 0.109 and 0.112 in training and validation group, respectively. The value of area under the ROCs were 0.813 (p<0.001) in the primary cohort and 0.819 (p<0.001) in the validation cohort. Through the calibration curves (as seen in the figures), nomogram prediction proved to have excellent agreement with actual metastatic diseases. Conclusion. A new nomogram was created that can evaluate synchronous metastatic diseases in patients with GISTs.http://dx.doi.org/10.1155/2020/8493707 |
| spellingShingle | Yuqiang Li Guangfeng Zhang Xiangping Song Lilan Zhao Cenap Güngör Dan Wang Wenxue Liu Yan Huang Fengbo Tan Establishment and Verification of Synchronous Metastatic Nomogram for Gastrointestinal Stromal Tumors (GISTs): A Population-Based Analysis Gastroenterology Research and Practice |
| title | Establishment and Verification of Synchronous Metastatic Nomogram for Gastrointestinal Stromal Tumors (GISTs): A Population-Based Analysis |
| title_full | Establishment and Verification of Synchronous Metastatic Nomogram for Gastrointestinal Stromal Tumors (GISTs): A Population-Based Analysis |
| title_fullStr | Establishment and Verification of Synchronous Metastatic Nomogram for Gastrointestinal Stromal Tumors (GISTs): A Population-Based Analysis |
| title_full_unstemmed | Establishment and Verification of Synchronous Metastatic Nomogram for Gastrointestinal Stromal Tumors (GISTs): A Population-Based Analysis |
| title_short | Establishment and Verification of Synchronous Metastatic Nomogram for Gastrointestinal Stromal Tumors (GISTs): A Population-Based Analysis |
| title_sort | establishment and verification of synchronous metastatic nomogram for gastrointestinal stromal tumors gists a population based analysis |
| url | http://dx.doi.org/10.1155/2020/8493707 |
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