Peritoneal resident macrophages constitute an immunosuppressive environment in peritoneal metastasized colorectal cancer

Peritoneal resident macrophages constitute an immunosuppressive environment in peritoneal metastasized colorectal cancer

Abstract Patients with peritoneal metastasized colorectal cancer (PM-CRC) have a dismal prognosis. We hypothesized that an immunosuppressive environment in the peritoneal cavity underlies poor prognosis. We define the composition of the human peritoneal immune system (PerIS) using single-cell techno...

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Main Authors: J. Saris, A. Y. F. Li Yim, S. Bootsma, K. J. Lenos, R. Franco Fernandez, H. N. Khan, J. Verhoeff, D. Poel, N. M. Mrzlikar, L. Xiong, M. P. Schijven, N. C. T. van Grieken, O. Kranenburg, M. E. Wildenberg, A. Logiantara, C. Jongerius, J. J. Garcia Vallejo, S. S. Gisbertz, S. Derks, J. B. Tuynman, G. R. A. M. D’Haens, L. Vermeulen, J. Grootjans
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58999-6
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