Antibacterial activity of biodentine against Enterococcus faecalis: a systematic review
IntroductionBiodentine is a well-known endodontic material that is applied in various endodontic therapies. Enterococcus faecalis (E. faecalis) is associated with endodontic failure and persistent periapical infection. The purpose of this systematic review was to summarize the available evidence reg...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Dental Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fdmed.2024.1498353/full |
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| author | Hasan Subhi Nashwah Subhi Salah Alhaidary Mahmood S. Azeez Abedelmalek Kalefh Tabnjh Abedelmalek Kalefh Tabnjh Abedelmalek Kalefh Tabnjh |
| author_facet | Hasan Subhi Nashwah Subhi Salah Alhaidary Mahmood S. Azeez Abedelmalek Kalefh Tabnjh Abedelmalek Kalefh Tabnjh Abedelmalek Kalefh Tabnjh |
| author_sort | Hasan Subhi |
| collection | DOAJ |
| description | IntroductionBiodentine is a well-known endodontic material that is applied in various endodontic therapies. Enterococcus faecalis (E. faecalis) is associated with endodontic failure and persistent periapical infection. The purpose of this systematic review was to summarize the available evidence regarding the antibacterial activity of Biodentine against E. faecalis and to compare it to other commercial endodontic materials.MethodsAn electronic search of literature was conducted in PubMed, Scopus, Web of Science, and Google Scholar in addition to a manual search in specialized journals up to May 2024. The eligibility criteria, data extraction, and evaluation of risk of bias were assessed by two independent authors. The risk of bias was evaluated in accordance with Modified CONSORT checklist items for pre-clinical in vitro studies on dental materials.ResultsOut of 343 studies, thirty-seven fulfilled the inclusion criteria and were included in this review. Thirty studies reported a good antibacterial efficacy of Biodentine against E. faecalis. Biodentine was superior to or, at least, as efficacious as MTA, MTA Angelus, GIC, RMGIC, DiaRoot BioAggregate, NeoPutty, iRoot FS, MTA Repair HP, MTA Biorep, Well-Root PT, Activa, NeoMTA 2, Calcimol LC, TotalFill, and IRM. The findings were supported by studies with medium to high risk of bias (low quality).ConclusionsConsidering the limitations of this systematic review, there is accumulating evidence on the antibacterial activity of Biodentine against E. faecalis in context of endodontics. However, randomized clinical trials with well-designed and robust methodologies are required in order to provide information about its clinical behaviour. |
| format | Article |
| id | doaj-art-b307c198898c4187a0a105856529171c |
| institution | Kabale University |
| issn | 2673-4915 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Dental Medicine |
| spelling | doaj-art-b307c198898c4187a0a105856529171c2025-01-21T08:36:55ZengFrontiers Media S.A.Frontiers in Dental Medicine2673-49152025-01-01510.3389/fdmed.2024.14983531498353Antibacterial activity of biodentine against Enterococcus faecalis: a systematic reviewHasan Subhi0Nashwah Subhi1Salah Alhaidary2Mahmood S. Azeez3Abedelmalek Kalefh Tabnjh4Abedelmalek Kalefh Tabnjh5Abedelmalek Kalefh Tabnjh6School of Dental Sciences, Universiti Sains Malaysia, Kelantan, MalaysiaDepartment of Prosthetic Dentistry, College of Dentistry, University of Mosul, Mosul, IraqDepartment of Orthodontics, Faculty of Dentistry, Ibn Al-Nafis University, Sana’a, YemenPharmacure Pharmacy, Azhar Private Hospital, Muscat, Sultanate of OmanDepartment of Cariology, Odontology School, Sahlgrenska Academy, Gothenburg University, Göteborg, SwedenDepartment of Applied Dental Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, JordanDental Research Unit, Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IndiaIntroductionBiodentine is a well-known endodontic material that is applied in various endodontic therapies. Enterococcus faecalis (E. faecalis) is associated with endodontic failure and persistent periapical infection. The purpose of this systematic review was to summarize the available evidence regarding the antibacterial activity of Biodentine against E. faecalis and to compare it to other commercial endodontic materials.MethodsAn electronic search of literature was conducted in PubMed, Scopus, Web of Science, and Google Scholar in addition to a manual search in specialized journals up to May 2024. The eligibility criteria, data extraction, and evaluation of risk of bias were assessed by two independent authors. The risk of bias was evaluated in accordance with Modified CONSORT checklist items for pre-clinical in vitro studies on dental materials.ResultsOut of 343 studies, thirty-seven fulfilled the inclusion criteria and were included in this review. Thirty studies reported a good antibacterial efficacy of Biodentine against E. faecalis. Biodentine was superior to or, at least, as efficacious as MTA, MTA Angelus, GIC, RMGIC, DiaRoot BioAggregate, NeoPutty, iRoot FS, MTA Repair HP, MTA Biorep, Well-Root PT, Activa, NeoMTA 2, Calcimol LC, TotalFill, and IRM. The findings were supported by studies with medium to high risk of bias (low quality).ConclusionsConsidering the limitations of this systematic review, there is accumulating evidence on the antibacterial activity of Biodentine against E. faecalis in context of endodontics. However, randomized clinical trials with well-designed and robust methodologies are required in order to provide information about its clinical behaviour.https://www.frontiersin.org/articles/10.3389/fdmed.2024.1498353/fullantibacterialbiodentineEnterococcus faecalisendodontic treatmentendodontic failuresystematic review |
| spellingShingle | Hasan Subhi Nashwah Subhi Salah Alhaidary Mahmood S. Azeez Abedelmalek Kalefh Tabnjh Abedelmalek Kalefh Tabnjh Abedelmalek Kalefh Tabnjh Antibacterial activity of biodentine against Enterococcus faecalis: a systematic review Frontiers in Dental Medicine antibacterial biodentine Enterococcus faecalis endodontic treatment endodontic failure systematic review |
| title | Antibacterial activity of biodentine against Enterococcus faecalis: a systematic review |
| title_full | Antibacterial activity of biodentine against Enterococcus faecalis: a systematic review |
| title_fullStr | Antibacterial activity of biodentine against Enterococcus faecalis: a systematic review |
| title_full_unstemmed | Antibacterial activity of biodentine against Enterococcus faecalis: a systematic review |
| title_short | Antibacterial activity of biodentine against Enterococcus faecalis: a systematic review |
| title_sort | antibacterial activity of biodentine against enterococcus faecalis a systematic review |
| topic | antibacterial biodentine Enterococcus faecalis endodontic treatment endodontic failure systematic review |
| url | https://www.frontiersin.org/articles/10.3389/fdmed.2024.1498353/full |
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