The clinical value of serum sirtuin-1 concentration in the diagnosis of metabolic dysfunction-associated steatotic liver disease
Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease and can affect individuals without producing any symptoms. We aimed to explore the value of serum sirtuin-1 (Sirt-1) in the diagnosis of MASLD. Methods This case-control s...
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2025-01-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-025-03613-8 |
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| author | Farshad Amirkhizi Mahdiyeh Taghizadeh Banafshe Khalese-Ranjbar Soudabeh Hamedi-Shahraki Somayyeh Asghari |
| author_facet | Farshad Amirkhizi Mahdiyeh Taghizadeh Banafshe Khalese-Ranjbar Soudabeh Hamedi-Shahraki Somayyeh Asghari |
| author_sort | Farshad Amirkhizi |
| collection | DOAJ |
| description | Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease and can affect individuals without producing any symptoms. We aimed to explore the value of serum sirtuin-1 (Sirt-1) in the diagnosis of MASLD. Methods This case-control study analyzed data collected from 190 individuals aged 20 to 60 years. Anthropometric parameters, demographic information, and serum biochemical variables—including glycemic parameters, lipid profiles, liver enzymes, and Sirt-1 levels—were assessed. The correlation between serum Sirt-1 and biochemical variables was examined using Pearson’s correlation coefficient. Receiver operating characteristic (ROC) curve analysis was employed to evaluate the diagnostic value of serum Sirt-1 in the context of MASLD. Results Serum Sirt-1 levels was significantly lower in the MASLD group (p < 0.001) and was inversely correlated with serum insulin (r = -0.163, p = 0.025), HOMA-IR (r = -0.169, p = 0.020) and triglyceride (r = -0.190, p = 0.009) and positively correlated with serum levels of high-density lipoprotein cholesterol (HDL-C) (r = 0.214, p = 0.003). The area under the curve (AUC) of Sirt-1 to predict the presence of MASLD was 0.76 (p < 0.001, 95% CI: 0.69, 0.82) with a sensitivity of 78.9, specificity of 61.1, positive predictive value (PPV) of 67.0%, and negative predictive value (NPV) of 74.0%. The optimal cutoff, determined using Youden’s index, was 23.75 ng/mL. This indicates that serum Sirt-1 levels below 23.75 ng/mL may be indicative of MASLD. Conclusions The present study demonstrated that serum Sirt-1 levels were significantly lower in patients with MASLD. Furthermore, these levels were correlated with various metabolic parameters, including insulin resistance and the serum lipid profile. A serum Sirt-1 level below the cutoff of 23.75 ng/mL exhibited a significant association with the presence of MASLD, suggesting its potential utility in identifying patients with this condition. |
| format | Article |
| id | doaj-art-b30499a8636f4a2eb836d9749478030d |
| institution | Kabale University |
| issn | 1471-230X |
| language | English |
| publishDate | 2025-01-01 |
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| series | BMC Gastroenterology |
| spelling | doaj-art-b30499a8636f4a2eb836d9749478030d2025-01-26T12:36:26ZengBMCBMC Gastroenterology1471-230X2025-01-012511910.1186/s12876-025-03613-8The clinical value of serum sirtuin-1 concentration in the diagnosis of metabolic dysfunction-associated steatotic liver diseaseFarshad Amirkhizi0Mahdiyeh Taghizadeh1Banafshe Khalese-Ranjbar2Soudabeh Hamedi-Shahraki3Somayyeh Asghari4Department of Nutrition, School of Public Health, Zabol University of Medical SciencesDepartment of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical SciencesDepartment of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical SciencesDepartment of Epidemiology and Biostatistics, School of Public Health, Zabol University of Medical SciencesDepartment of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical SciencesAbstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease and can affect individuals without producing any symptoms. We aimed to explore the value of serum sirtuin-1 (Sirt-1) in the diagnosis of MASLD. Methods This case-control study analyzed data collected from 190 individuals aged 20 to 60 years. Anthropometric parameters, demographic information, and serum biochemical variables—including glycemic parameters, lipid profiles, liver enzymes, and Sirt-1 levels—were assessed. The correlation between serum Sirt-1 and biochemical variables was examined using Pearson’s correlation coefficient. Receiver operating characteristic (ROC) curve analysis was employed to evaluate the diagnostic value of serum Sirt-1 in the context of MASLD. Results Serum Sirt-1 levels was significantly lower in the MASLD group (p < 0.001) and was inversely correlated with serum insulin (r = -0.163, p = 0.025), HOMA-IR (r = -0.169, p = 0.020) and triglyceride (r = -0.190, p = 0.009) and positively correlated with serum levels of high-density lipoprotein cholesterol (HDL-C) (r = 0.214, p = 0.003). The area under the curve (AUC) of Sirt-1 to predict the presence of MASLD was 0.76 (p < 0.001, 95% CI: 0.69, 0.82) with a sensitivity of 78.9, specificity of 61.1, positive predictive value (PPV) of 67.0%, and negative predictive value (NPV) of 74.0%. The optimal cutoff, determined using Youden’s index, was 23.75 ng/mL. This indicates that serum Sirt-1 levels below 23.75 ng/mL may be indicative of MASLD. Conclusions The present study demonstrated that serum Sirt-1 levels were significantly lower in patients with MASLD. Furthermore, these levels were correlated with various metabolic parameters, including insulin resistance and the serum lipid profile. A serum Sirt-1 level below the cutoff of 23.75 ng/mL exhibited a significant association with the presence of MASLD, suggesting its potential utility in identifying patients with this condition.https://doi.org/10.1186/s12876-025-03613-8Metabolic dysfunction-associated steatotic liver diseaseSirtuin 1Diagnostic biomarkerCase-control |
| spellingShingle | Farshad Amirkhizi Mahdiyeh Taghizadeh Banafshe Khalese-Ranjbar Soudabeh Hamedi-Shahraki Somayyeh Asghari The clinical value of serum sirtuin-1 concentration in the diagnosis of metabolic dysfunction-associated steatotic liver disease BMC Gastroenterology Metabolic dysfunction-associated steatotic liver disease Sirtuin 1 Diagnostic biomarker Case-control |
| title | The clinical value of serum sirtuin-1 concentration in the diagnosis of metabolic dysfunction-associated steatotic liver disease |
| title_full | The clinical value of serum sirtuin-1 concentration in the diagnosis of metabolic dysfunction-associated steatotic liver disease |
| title_fullStr | The clinical value of serum sirtuin-1 concentration in the diagnosis of metabolic dysfunction-associated steatotic liver disease |
| title_full_unstemmed | The clinical value of serum sirtuin-1 concentration in the diagnosis of metabolic dysfunction-associated steatotic liver disease |
| title_short | The clinical value of serum sirtuin-1 concentration in the diagnosis of metabolic dysfunction-associated steatotic liver disease |
| title_sort | clinical value of serum sirtuin 1 concentration in the diagnosis of metabolic dysfunction associated steatotic liver disease |
| topic | Metabolic dysfunction-associated steatotic liver disease Sirtuin 1 Diagnostic biomarker Case-control |
| url | https://doi.org/10.1186/s12876-025-03613-8 |
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