The impact of statin-ezetimibe combination therapy versus statin monotherapy on coronary plaque regression in patients with acute coronary syndrome: a meta-analysis
Objective: To investigate the effects of statin monotherapy and statin-ezetimibe combination therapy on coronary plaque regression in acute coronary syndrome patients. Methods: The systematic review was conducted from July to September 2022 and comprised search on PubMed, ScienceDirect and Cochrane...
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Pakistan Medical Association
2024-07-01
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| Series: | Journal of the Pakistan Medical Association |
| Online Access: | https://jpma.org.pk/index.php/public_html/article/view/21452 |
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| author | Yusra Pintaningrum Ketut Angga Aditya Putra Pramana |
| author_facet | Yusra Pintaningrum Ketut Angga Aditya Putra Pramana |
| author_sort | Yusra Pintaningrum |
| collection | DOAJ |
| description |
Objective: To investigate the effects of statin monotherapy and statin-ezetimibe combination therapy on coronary
plaque regression in acute coronary syndrome patients.
Methods: The systematic review was conducted from July to September 2022 and comprised search on PubMed,
ScienceDirect and Cochrane databases to identify studies from January 2010 to July 2022 assessing the effects of
statin-ezetimibe combination therapy versus statin monotherapy on coronary plaque regression in patients with
acute coronary syndrome. The outcomes of interest were total atheroma volume, plaque volume, and percent
atheroma volume assessed by intravascular ultrasound. Meta-analyses were performed on the studies, and mean
differences with 95% confidence interval were estimated using Review Manager v5.4.
Results: Of the 730 studies identified, 12(1.64%) were shortlisted, and, of them, 5(41.7%) were analysed in detail.
There were a total of 557 patients with a mean follow-up of 9 ± 2.43 months. The difference between baseline and
follow-up showed significant lowering in total atheroma volume, plaque volume, and percent atheroma volume
(p<0.05) in the patients who were receiving statin-ezetimibe combination therapy.
Conclusion: Adding ezetimibe to statin medication was found to be significantly more successful in reducing
coronary plaque than statin monotherapy.
Key Words: Ezetimibe, Plaque, Atherosclerotic, Hydroxy, Coronary, Ultrasonography, Interventional.
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| format | Article |
| id | doaj-art-b2fc552aba45486f88f30e269ec72d28 |
| institution | DOAJ |
| issn | 0030-9982 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Pakistan Medical Association |
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| series | Journal of the Pakistan Medical Association |
| spelling | doaj-art-b2fc552aba45486f88f30e269ec72d282025-08-20T02:41:40ZengPakistan Medical AssociationJournal of the Pakistan Medical Association0030-99822024-07-01746 (Supple)10.47391/JPMA.S6-ACSA-05The impact of statin-ezetimibe combination therapy versus statin monotherapy on coronary plaque regression in patients with acute coronary syndrome: a meta-analysisYusra Pintaningrum0Ketut Angga Aditya Putra Pramana1Department of Cardiology & Vascular Medicine, West Nusa Tenggara General Hospital, Mataram University, Indonesia.General Practitioner, Bhayangkara Mataram Hospital, Indonesia. Objective: To investigate the effects of statin monotherapy and statin-ezetimibe combination therapy on coronary plaque regression in acute coronary syndrome patients. Methods: The systematic review was conducted from July to September 2022 and comprised search on PubMed, ScienceDirect and Cochrane databases to identify studies from January 2010 to July 2022 assessing the effects of statin-ezetimibe combination therapy versus statin monotherapy on coronary plaque regression in patients with acute coronary syndrome. The outcomes of interest were total atheroma volume, plaque volume, and percent atheroma volume assessed by intravascular ultrasound. Meta-analyses were performed on the studies, and mean differences with 95% confidence interval were estimated using Review Manager v5.4. Results: Of the 730 studies identified, 12(1.64%) were shortlisted, and, of them, 5(41.7%) were analysed in detail. There were a total of 557 patients with a mean follow-up of 9 ± 2.43 months. The difference between baseline and follow-up showed significant lowering in total atheroma volume, plaque volume, and percent atheroma volume (p<0.05) in the patients who were receiving statin-ezetimibe combination therapy. Conclusion: Adding ezetimibe to statin medication was found to be significantly more successful in reducing coronary plaque than statin monotherapy. Key Words: Ezetimibe, Plaque, Atherosclerotic, Hydroxy, Coronary, Ultrasonography, Interventional. https://jpma.org.pk/index.php/public_html/article/view/21452 |
| spellingShingle | Yusra Pintaningrum Ketut Angga Aditya Putra Pramana The impact of statin-ezetimibe combination therapy versus statin monotherapy on coronary plaque regression in patients with acute coronary syndrome: a meta-analysis Journal of the Pakistan Medical Association |
| title | The impact of statin-ezetimibe combination therapy versus statin monotherapy on coronary plaque regression in patients with acute coronary syndrome: a meta-analysis |
| title_full | The impact of statin-ezetimibe combination therapy versus statin monotherapy on coronary plaque regression in patients with acute coronary syndrome: a meta-analysis |
| title_fullStr | The impact of statin-ezetimibe combination therapy versus statin monotherapy on coronary plaque regression in patients with acute coronary syndrome: a meta-analysis |
| title_full_unstemmed | The impact of statin-ezetimibe combination therapy versus statin monotherapy on coronary plaque regression in patients with acute coronary syndrome: a meta-analysis |
| title_short | The impact of statin-ezetimibe combination therapy versus statin monotherapy on coronary plaque regression in patients with acute coronary syndrome: a meta-analysis |
| title_sort | impact of statin ezetimibe combination therapy versus statin monotherapy on coronary plaque regression in patients with acute coronary syndrome a meta analysis |
| url | https://jpma.org.pk/index.php/public_html/article/view/21452 |
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