Evaluation of the efficacy of topical Nigella sativa L. with vinegar in the treatment of acne vulgaris: A randomized controlled trial
Background and objectives: Acne vulgaris stands as the prevailing dermatological condition on a global scale, prompting exploration into diverse therapeutic modalities. Hence, this study aimed to assess the efficacy of a formulation comprising Kalonji (Nigella sativa) and Sirka (vinegar) in comparis...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-03-01
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| Series: | Journal of Dermatologic Science and Cosmetic Technology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950306X25000020 |
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| author | Shaikh Nisar Ahmed Abbas Arshan Horti Muhammed Rashid Allapat Mamadapur Saba Abdul Razzaq Farooqui Shazia Parveen Nazim Husain |
| author_facet | Shaikh Nisar Ahmed Abbas Arshan Horti Muhammed Rashid Allapat Mamadapur Saba Abdul Razzaq Farooqui Shazia Parveen Nazim Husain |
| author_sort | Shaikh Nisar Ahmed Abbas |
| collection | DOAJ |
| description | Background and objectives: Acne vulgaris stands as the prevailing dermatological condition on a global scale, prompting exploration into diverse therapeutic modalities. Hence, this study aimed to assess the efficacy of a formulation comprising Kalonji (Nigella sativa) and Sirka (vinegar) in comparison to benzoyl peroxide 5 % for the treatment of acne vulgaris. Methods: In this open-label randomized controlled trial, 40 participants with acne in the age bracket of 13–40 years completed the 28-day treatment period. The Unani group received a Nigella sativa seed powder and cane vinegar, while the control group received benzoyl peroxide 5 % gel. Both interventions were applied topically at night. Primary outcomes encompassed changes in the Global Acne Grading System (GAGS) and Cook’s Acne Grading Scale using PSAG scores. The secondary outcome was the change in Quality of Life assessed through the Cardiff Acne Disability Index (CADI). Safety evaluations included baseline and post-treatment measurements of hemograms, serum creatinine, serum bilirubin, and random blood sugar levels. Results: The GAGS scores showed a mean difference of −2.600 (95 % CI: −5.770 - 0.570, d=0.57, p = 0.105), PSAG scores exhibited a mean difference of −0.600 (95 % CI: −1.793 - 0.593, d=0.49, p = 0.315), and CADI scores displayed a mean difference of −1.500 (95 % CI: −3.470 - 0.470, d=0.32, p = 0.132) at the trial conclusion. Conclusions: This trial suggests that the formulation may have therapeutic potential as an alternative acne treatment. Further studies with larger sample sizes and extended follow-up periods are recommended. Clinical trial registration: The clinical trial was registered with Clinical Trial Registry – India under the registration number CTRI/2022/05/042368 on May 4, 2022. |
| format | Article |
| id | doaj-art-b2fa94b7423e41eeb210361db345f918 |
| institution | Kabale University |
| issn | 2950-306X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Journal of Dermatologic Science and Cosmetic Technology |
| spelling | doaj-art-b2fa94b7423e41eeb210361db345f9182025-08-20T03:31:37ZengKeAi Communications Co., Ltd.Journal of Dermatologic Science and Cosmetic Technology2950-306X2025-03-012110006910.1016/j.jdsct.2025.100069Evaluation of the efficacy of topical Nigella sativa L. with vinegar in the treatment of acne vulgaris: A randomized controlled trialShaikh Nisar Ahmed Abbas0Arshan Horti1Muhammed Rashid Allapat2Mamadapur Saba Abdul Razzaq3Farooqui Shazia Parveen4Nazim Husain5Department of Moalajat (Medicine), Luqman Unani Medical College Hospital and Research Center, Bijapur, Karnataka 586101, IndiaDepartment of Moalajat (Medicine), Luqman Unani Medical College Hospital and Research Center, Bijapur, Karnataka 586101, IndiaDepartment of Moalajat (Medicine), Luqman Unani Medical College Hospital and Research Center, Bijapur, Karnataka 586101, IndiaDepartment of Moalajat (Medicine), Luqman Unani Medical College Hospital and Research Center, Bijapur, Karnataka 586101, IndiaRegional Research Institute of Unani Medicine, Chennai, Tamil Nadu 600013, IndiaRegional Research Institute of Unani Medicine, Silchar, Assam 788014, India; Corresponding author.Background and objectives: Acne vulgaris stands as the prevailing dermatological condition on a global scale, prompting exploration into diverse therapeutic modalities. Hence, this study aimed to assess the efficacy of a formulation comprising Kalonji (Nigella sativa) and Sirka (vinegar) in comparison to benzoyl peroxide 5 % for the treatment of acne vulgaris. Methods: In this open-label randomized controlled trial, 40 participants with acne in the age bracket of 13–40 years completed the 28-day treatment period. The Unani group received a Nigella sativa seed powder and cane vinegar, while the control group received benzoyl peroxide 5 % gel. Both interventions were applied topically at night. Primary outcomes encompassed changes in the Global Acne Grading System (GAGS) and Cook’s Acne Grading Scale using PSAG scores. The secondary outcome was the change in Quality of Life assessed through the Cardiff Acne Disability Index (CADI). Safety evaluations included baseline and post-treatment measurements of hemograms, serum creatinine, serum bilirubin, and random blood sugar levels. Results: The GAGS scores showed a mean difference of −2.600 (95 % CI: −5.770 - 0.570, d=0.57, p = 0.105), PSAG scores exhibited a mean difference of −0.600 (95 % CI: −1.793 - 0.593, d=0.49, p = 0.315), and CADI scores displayed a mean difference of −1.500 (95 % CI: −3.470 - 0.470, d=0.32, p = 0.132) at the trial conclusion. Conclusions: This trial suggests that the formulation may have therapeutic potential as an alternative acne treatment. Further studies with larger sample sizes and extended follow-up periods are recommended. Clinical trial registration: The clinical trial was registered with Clinical Trial Registry – India under the registration number CTRI/2022/05/042368 on May 4, 2022.http://www.sciencedirect.com/science/article/pii/S2950306X25000020Busoor-e-LabaniyyaKalonjiSirkaUnani medicine |
| spellingShingle | Shaikh Nisar Ahmed Abbas Arshan Horti Muhammed Rashid Allapat Mamadapur Saba Abdul Razzaq Farooqui Shazia Parveen Nazim Husain Evaluation of the efficacy of topical Nigella sativa L. with vinegar in the treatment of acne vulgaris: A randomized controlled trial Journal of Dermatologic Science and Cosmetic Technology Busoor-e-Labaniyya Kalonji Sirka Unani medicine |
| title | Evaluation of the efficacy of topical Nigella sativa L. with vinegar in the treatment of acne vulgaris: A randomized controlled trial |
| title_full | Evaluation of the efficacy of topical Nigella sativa L. with vinegar in the treatment of acne vulgaris: A randomized controlled trial |
| title_fullStr | Evaluation of the efficacy of topical Nigella sativa L. with vinegar in the treatment of acne vulgaris: A randomized controlled trial |
| title_full_unstemmed | Evaluation of the efficacy of topical Nigella sativa L. with vinegar in the treatment of acne vulgaris: A randomized controlled trial |
| title_short | Evaluation of the efficacy of topical Nigella sativa L. with vinegar in the treatment of acne vulgaris: A randomized controlled trial |
| title_sort | evaluation of the efficacy of topical nigella sativa l with vinegar in the treatment of acne vulgaris a randomized controlled trial |
| topic | Busoor-e-Labaniyya Kalonji Sirka Unani medicine |
| url | http://www.sciencedirect.com/science/article/pii/S2950306X25000020 |
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