Adjuvant effects elicited by novel oligosaccharide variants of detoxified meningococcal lipopolysaccharides on Neisseria meningitidis recombinant PorA protein: a comparison in mice.

Adjuvant effects elicited by novel oligosaccharide variants of detoxified meningococcal lipopolysaccharides on Neisseria meningitidis recombinant PorA protein: a comparison in mice.

Neisseria meningitidis lipopolysaccharide (LPS) has adjuvant properties that can be exploited to assist vaccine immunogenicity. The modified penta-acylated LPS retains the adjuvant properties of hexa-acylated LPS but has a reduced toxicity profile. In this study we investigated whether two modified...

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Bibliographic Details
Main Authors: Ojas H Mehta, Gunnstein Norheim, J Claire Hoe, Christine S Rollier, Jerry C Nagaputra, Katherine Makepeace, Muhammad Saleem, Hannah Chan, David J P Ferguson, Claire Jones, Manish Sadarangani, Derek W Hood, Ian Feavers, Jeremy P Derrick, Andrew J Pollard, E Richard Moxon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0115713
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